Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A2 | P43004 | 1/20 | 0.68 |
| ▸ | RAB9A | P51151 | 12/20 | 0.65 |
| ▸ | MAPT | P10636 | 9/20 | 0.65 |
| ▸ | LMNA | P02545 | 5/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.65 |
| ▸ | POLB | P06746 | 2/20 | 0.65 |
| ▸ | TP53 | P04637 | 1/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.65 |
| ▸ | NPC1 | O15118 | 10/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.51 |
| ▸ | HPGD | P15428 | 4/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.49 |
| ▸ | RELA | Q04206 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16155536 | 0.86 | SMN1; SMN2 (0.68) | SLC1A2RAB9AMAPTLMNAALDH1A1 | |
| SCHEMBL30674412 | 0.81 | SLC1A2 (1.00) | SLC1A2RAB9AMAPTLMNAALDH1A1 | |
| SCHEMBL14685055 | 0.81 | SLC1A2 (1.00) | SLC1A2RAB9AMAPTLMNAALDH1A1 | |
| SCHEMBL18079731 | 0.80 | SLC1A2 (0.74) | SLC1A2RAB9AMAPTLMNAALDH1A1 | |
| SCHEMBL10480550 | 0.78 | POLB (0.60) | SLC1A2RAB9AMAPTLMNAALDH1A1 | |
| SCHEMBL16155566 | 0.75 | SLC1A2 (0.59) | SLC1A2RAB9AMAPTLMNAALDH1A1 | |
| SCHEMBL16155538 | 0.75 | SLC1A2 (0.56) | SLC1A2RAB9AMAPTLMNAALDH1A1 | |
| SCHEMBL18079704 | 0.72 | SMN1; SMN2 (0.55) | SLC1A2RAB9AMAPTLMNAALDH1A1 | |
| SCHEMBL4904149 | 0.71 | SMN1; SMN2 (0.55) | RAB9AMAPTLMNAALDH1A1NPC1 | |
| SCHEMBL1752819 | 0.71 | RAB9A (0.62) | RAB9AMAPTLMNAALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9447075-B2 | Pyridazine derivatives as EAAT2 activators | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2016-09-20 | — | — | US | disclosed |
| US-9447075-B2 | Pyridazine derivatives as EAAT2 activators | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2016-09-20 | — | — | US | disclosed |