Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.55 |
| ▸ | RAB9A | P51151 | 7/20 | 0.55 |
| ▸ | NPC1 | O15118 | 6/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | GSK3B | P49841 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 7/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18079706 | 0.85 | SMN1; SMN2 (0.68) | SMN1; SMN2RAB9ANPC1MAPTLMNA | |
| SCHEMBL18079702 | 0.81 | SLC1A2 (0.71) | SMN1; SMN2RAB9ANPC1MAPTLMNA | |
| SCHEMBL18079705 | 0.72 | SLC1A2 (0.68) | SMN1; SMN2RAB9ANPC1MAPTLMNA | |
| SCHEMBL18080851 | 0.72 | SLC1A2 (0.67) | SMN1; SMN2RAB9ANPC1MAPTLMNA | |
| SCHEMBL16155539 | 0.72 | RAB9A (0.45) | SMN1; SMN2RAB9ANPC1MAPTLMNA | |
| SCHEMBL5024085 | 0.71 | GSK3B (1.00) | SMN1; SMN2RAB9ANPC1CYP1A2CYP3A4 | |
| SCHEMBL16155532 | 0.71 | RAB9A (0.41) | SMN1; SMN2RAB9ANPC1MAPTLMNA | |
| SCHEMBL18079719 | 0.70 | RAB9A (0.57) | SMN1; SMN2RAB9ANPC1MAPTLMNA | |
| SCHEMBL16155536 | 0.69 | SMN1; SMN2 (0.68) | SMN1; SMN2RAB9ANPC1MAPTLMNA | |
| SCHEMBL30883908 | 0.69 | KMT2A (0.50) | SMN1; SMN2RAB9ANPC1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9447075-B2 | Pyridazine derivatives as EAAT2 activators | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2016-09-20 | — | — | US | disclosed |
| US-9447075-B2 | Pyridazine derivatives as EAAT2 activators | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2016-09-20 | — | — | US | disclosed |