Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 9/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.45 |
| ▸ | NPC1 | O15118 | 7/20 | 0.45 |
| ▸ | TP53 | P04637 | 5/20 | 0.45 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 9/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | SMURF2 | Q9HAU4 | 3/20 | 0.43 |
| ▸ | SMURF1 | Q9HCE7 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11971366 | 0.81 | S1PR1 (0.57) | SMURF2SMURF1 | |
| SCHEMBL1805574 | 0.72 | S1PR1 (0.63) | RAB9AHSD17B10CYP1A2CYP2D6SMN1; SMN2 | |
| SCHEMBL1814499 | 0.67 | RAB9A (0.67) | RAB9AHSD17B10MAPK1CYP1A2CYP2D6 | |
| SCHEMBL1812390 | 0.66 | S1PR1 (0.61) | RAB9AHSD17B10MAPK1CYP1A2CYP2D6 | |
| SCHEMBL1816395 | 0.66 | S1PR1 (0.57) | RAB9AHSD17B10MAPK1CYP1A2CYP2D6 | |
| SCHEMBL1814756 | 0.65 | S1PR1 (0.57) | RAB9ASMN1; SMN2NPC1HTTMAPT | |
| SCHEMBL1816689 | 0.65 | S1PR1 (0.57) | RAB9AHSD17B10MAPK1CYP1A2CYP2D6 | |
| SCHEMBL5220501 | 0.65 | HTR2C (0.57) | RAB9AMAPK1CYP2C19SMN1; SMN2NPC1 | |
| SCHEMBL17261642 | 0.64 | SMURF2 (0.59) | RAB9AHSD17B10MAPK1CYP1A2CYP2D6 | |
| SCHEMBL1815111 | 0.64 | ALDH1A1 (0.66) | HSD17B10SMN1; SMN2TP53HTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2493866-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS | Bristol-Myers Squibb Company (US) | 2012-09-05 | — | — | EP | disclosed |
| WO-2011059784-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-05-19 | — | — | WO | disclosed |