Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | TAS2R38 | P59533 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.30 |
| ▸ | MMP12 | P39900 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7191913 | 0.90 | — | — | |
| SCHEMBL12967699 | 0.78 | — | — | |
| SCHEMBL2891715 | 0.78 | CRBN (0.53) | ALDH1A1CRBNTAS2R38LMNAHSD17B10 | |
| SCHEMBL18082015 | 0.76 | CRBN (0.41) | TDP1ALDH1A1CRBNTAS2R38LMNA | |
| SCHEMBL25543214 | 0.75 | CACNA1C (0.37) | TDP1ALDH1A1LMNAHSD17B10KDM4E | |
| SCHEMBL3388817 | 0.75 | TGFBR1 (0.38) | TDP1ALDH1A1HSD17B10FFAR3KDM4E | |
| SCHEMBL9433582 | 0.74 | — | — | |
| SCHEMBL28247133 | 0.74 | — | — | |
| SCHEMBL10646872 | 0.74 | — | — | |
| SCHEMBL12967761 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2498780-B1 | N-9-SUBSTITUTED PURINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | HOFFMANN LA ROCHE (CH) | 2016-09-07 | — | — | EP | disclosed |