Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | TAS2R38 | P59533 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | MMP12 | P39900 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6448942 | 0.91 | ALDH1A1 (0.38) | CRBNTAS2R38KDM4ECA2PTGS1 | |
| SCHEMBL177640 | 0.84 | — | — | |
| SCHEMBL2891715 | 0.84 | CRBN (0.53) | CRBNTAS2R38KDM4ECA2PTGS1 | |
| SCHEMBL10918683 | 0.80 | ALDH1A1 (0.32) | ALDH1A1TDP1 | |
| SCHEMBL9424912 | 0.78 | CRBN (0.38) | CRBNTAS2R38KDM4ECA2PTGS1 | |
| SCHEMBL20827772 | 0.77 | — | — | |
| SCHEMBL18082014 | 0.76 | TDP1 (0.36) | CRBNTAS2R38KDM4ECA2PTGS1 | |
| SCHEMBL4851225 | 0.71 | CRBN (0.47) | CRBNTAS2R38KDM4ECA2PTGS1 | |
| SCHEMBL12168957 | 0.71 | CRBN (0.41) | CRBNTAS2R38KDM4ECA2PTGS1 | |
| SCHEMBL20671809 | 0.71 | CRBN (0.41) | CRBNTAS2R38KDM4ECA2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2498780-B1 | N-9-SUBSTITUTED PURINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | HOFFMANN LA ROCHE (CH) | 2016-09-07 | — | — | EP | disclosed |