Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHOA | P61586 | 1/20 | 0.57 |
| ▸ | MGLL | Q99685 | 8/20 | 0.56 |
| ▸ | HRH1 | P35367 | 2/20 | 0.55 |
| ▸ | CCR3 | P51677 | 2/20 | 0.55 |
| ▸ | RBP4 | P02753 | 1/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
| ▸ | PRSS12 | P56730 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1805362 | 0.88 | HRH1 (0.57) | MGLLHRH1CCR3HRH3PRSS12 | |
| SCHEMBL1808919 | 0.88 | MGLL (0.59) | MGLLHRH3 | |
| SCHEMBL1808355 | 0.88 | L3MBTL3 (0.58) | MGLLHRH1CCR3EPHX2HRH3 | |
| SCHEMBL1809338 | 0.87 | MGLL (0.73) | MGLLHRH1CCR3 | |
| SCHEMBL1808762 | 0.87 | HRH1 (0.70) | MGLLHRH1CCR3EPHX2HRH3 | |
| SCHEMBL1806803 | 0.87 | HRH3 (0.51) | MGLLEPHX2HRH3PRSS12 | |
| SCHEMBL1806214 | 0.86 | HRH1 (0.57) | MGLLHRH1CCR3HRH3 | |
| SCHEMBL1805983 | 0.86 | MGLL (0.67) | RHOAMGLLHRH1CCR3HRH3 | |
| SCHEMBL12188732 | 0.85 | MGLL (0.69) | MGLLHRH1CCR3HRH3PRSS12 | |
| SCHEMBL1806882 | 0.85 | MGLL (0.67) | MGLLHRH1CCR3HRH3PRSS12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9051296-B2 | Aryl carboxamide derivatives as TTX-S blockers | RAQUALIA PHARMA INC. (JP) | 2015-06-09 | — | — | US | disclosed |
| US-20120232052-A1 | ARYL CARBOXAMIDE DERIVATIVES AS TTX-S BLOCKERS | RAQUALIA PHARMA INC. (JP) | 2012-09-13 | — | — | US | disclosed |
| WO-2011058766-A1 | ARYL CARBOXAMIDE DERIVATIVES AS TTX-S BLOCKERS | RAQUALIA PHARMA INC. (JP) | 2011-05-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120232052-A1 | ARYL CARBOXAMIDE DERIVATIVES AS TTX-S BLOCKERS | SCN1B, SCN1A, SCN2B | RHOA 2595/4885MGLL 4513/4885HRH1 819/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.