Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAAT5 | Q96KN8 | 7/20 | 0.49 |
| ▸ | PLAAT4 | Q9UL19 | 7/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 3/20 | 0.44 |
| ▸ | CA2 | P00918 | 3/20 | 0.44 |
| ▸ | CA9 | Q16790 | 3/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | PLAAT3 | P53816 | 6/20 | 0.43 |
| ▸ | PLAAT2 | Q9NWW9 | 6/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19819194 | 1.00 | PLAAT5 (0.49) | PLAAT5PLAAT4NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL14703133 | 0.80 | PLAAT5 (0.54) | PLAAT5PLAAT4NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL19819193 | 0.78 | PLAAT5 (0.53) | PLAAT5PLAAT4NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL14703127 | 0.78 | PLAAT5 (0.53) | PLAAT5PLAAT4NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9212709 | 0.76 | SMN1; SMN2 (0.56) | NPC1RAB9ASMN1; SMN2CA12CA2 | |
| SCHEMBL11701636 | 0.76 | TRPV1 (0.46) | LMNA | |
| SCHEMBL11698633 | 0.75 | TRPV1 (0.48) | LMNA | |
| SCHEMBL9210616 | 0.73 | ABCB1 (0.50) | NPC1RAB9ASMN1; SMN2CA12CA2 | |
| SCHEMBL9214596 | 0.71 | SMN1; SMN2 (0.58) | NPC1RAB9ASMN1; SMN2LMNAGAA | |
| SCHEMBL9212059 | 0.71 | GPR52 (0.42) | NPC1RAB9ASMN1; SMN2CA12CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9879049-B2 | Glycopeptide antibiotic analogs effective against vancomycin-resistant bacterial strains | THE SCRIPPS RESEARCH INSTITUTE (US) | 2018-01-30 | — | — | US | disclosed |
| US-20160272682-A1 | GLYCOPEPTIDE ANTIBIOTIC ANALOGS EFFECTIVE AGAINST VANCOMYCIN-RESISTANT BACTERIAL STRAINS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2016-09-22 | — | — | US | disclosed |
| US-20160272682-A1 | GLYCOPEPTIDE ANTIBIOTIC ANALOGS EFFECTIVE AGAINST VANCOMYCIN-RESISTANT BACTERIAL STRAINS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2016-09-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160272682-A1 | GLYCOPEPTIDE ANTIBIOTIC ANALOGS EFFECTIVE AGAINST VANCOMYCIN-RESISTANT BACTERIAL STRAINS | DDOST, ANPEP, STT3A | PLAAT5 1392/4885PLAAT4 786/4885NPC1 2581/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.