SCHEMBL18089949

SCHEMBL18089949

c1ccc([Si](c2ccccc2)(c2cccc3c2sc2ccc(-c4nccc5c4sc4ccccc45)cc23)c2cccc3c2sc2ccc(-c4nccc5c4sc4ccccc45)cc23)cc1

nearest known ligand 0.36

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 1/20 0.36
LIMK1 P53667 1/20 0.34
TNKS O95271 1/20 0.32
TNKS2 Q9H2K2 1/20 0.32
ROCK1 Q13464 1/20 0.31
PTGIR P43119 1/20 0.31
MAPT P10636 1/20 0.31
PTPN7 P35236 1/20 0.30
DUSP3 P51452 1/20 0.30
PTPN12 Q05209 1/20 0.30
PTPN22 Q9Y2R2 1/20 0.30
HTR2B P41595 1/20 0.30
HTR5A P47898 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18090000 0.89 PRKDC (0.32) ALOX5LIMK1
SCHEMBL18090102 0.89 ALOX5 (0.30) ALOX5
SCHEMBL18089931 0.87 LIMK1 (0.35) ALOX5LIMK1TNKSTNKS2ROCK1
SCHEMBL18089918 0.86 ALOX5 (0.42) ALOX5LIMK1TNKSTNKS2PTGIR
SCHEMBL18090055 0.86 NPC1 (0.31) MAPT
SCHEMBL18090052 0.86 NPC1 (0.31) MAPT
SCHEMBL26238249 0.84 TNKS (0.37) ALOX5LIMK1TNKSTNKS2MAPT
SCHEMBL17754690 0.84 ALOX5 (0.43) ALOX5LIMK1TNKSTNKS2
SCHEMBL18089937 0.83 ALOX5 (0.38) ALOX5LIMK1
SCHEMBL18089910 0.83 ALOX5 (0.54) ALOX5LIMK1TNKSTNKS2PTGIR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9780316-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2017-10-03 US disclosed
US-9780316-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2017-10-03 US disclosed
US-20160276604-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2016-09-22 US disclosed
US-20160276604-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2016-09-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160276604-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES RB1, LEF1, BRD1 ALOX5 551/4885LIMK1 177/4885TNKS 2018/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.