SCHEMBL18089999

SCHEMBL18089999

c1ccc([Si](c2ccccc2)(c2cccc3c2oc2ccc(-c4cc5c(cn4)oc4ccccc45)cc23)c2cccc3c2sc2ccc(-c4cc5c(cn4)oc4ccccc45)cc23)cc1

nearest known ligand 0.32

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
PTPRF P10586 10/20 0.32
PTPN2 P17706 10/20 0.32
PTPN1 P18031 10/20 0.32
LIMK1 P53667 1/20 0.30
NPC1 O15118 1/20 0.30
MAPT P10636 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18090056 0.96 PTPRF (0.30) PTPRFPTPN2PTPN1NPC1MAPT
SCHEMBL18090053 0.96 PTPRF (0.30) PTPRFPTPN2PTPN1NPC1MAPT
SCHEMBL18090007 0.91 PTPRF (0.32) PTPRFPTPN2PTPN1LIMK1
SCHEMBL18089994 0.91 LIMK1 (0.34) PTPRFPTPN2PTPN1LIMK1NPC1
SCHEMBL18090101 0.90 ALOX5 (0.30)
SCHEMBL18090105 0.90 NPC1 (0.33) PTPRFPTPN2PTPN1NPC1MAPT
SCHEMBL18089921 0.89 NPC1 (0.36) PTPRFPTPN2PTPN1NPC1MAPT
SCHEMBL18090045 0.88 NPC1 (0.33) PTPRFPTPN2PTPN1LIMK1NPC1
SCHEMBL18089996 0.86 ALOX5 (0.44) PTPRFPTPN2PTPN1LIMK1
SCHEMBL18090004 0.84 LIMK1 (0.31) LIMK1NPC1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9780316-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2017-10-03 US disclosed
US-9780316-B2 Organic electroluminescent materials and devices UNIVERSAL DISPLAY CORPORATION (US) 2017-10-03 US disclosed
US-20160276604-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2016-09-22 US disclosed
US-20160276604-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES UNIVERSAL DISPLAY CORPORATION (US) 2016-09-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160276604-A1 ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES RB1, LEF1, BRD1 PTPRF 4540/4885PTPN2 3931/4885PTPN1 4043/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.