⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6731252 | 0.76 | UHRF1 (0.34) | — | |
| SCHEMBL6729852 | 0.76 | L3MBTL1 (0.36) | — | |
| SCHEMBL244894 | 0.73 | TDP1 (0.38) | — | |
| SCHEMBL2424257 | 0.71 | — | — | |
| SCHEMBL1453183 | 0.69 | TSHR (0.36) | — | |
| SCHEMBL6732251 | 0.69 | HRH3 (0.31) | — | |
| SCHEMBL1851761 | 0.69 | PDE1A (0.32) | — | |
| SCHEMBL1453413 | 0.67 | TLR8 (0.36) | — | |
| SCHEMBL5951974 | 0.67 | MAPT (0.38) | — | |
| SCHEMBL28275 | 0.67 | LOXL2 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4655069-A1 | PYRIDAZINES AS SARM1 INHIBITORS | Disarm Therapeutics, Inc. (US) | 2025-12-03 | — | — | EP | disclosed |
| WO-2024158775-A1 | PYRIDAZINES AS SARM1 INHIBITORS | DISARM THERAPEUTICS, INC. (US) | 2024-08-02 | — | — | WO | disclosed |
| US-20110124652-A1 | Chemical Compounds and Uses | SMITHKLINE BEECHAM CORPORATION | 2011-05-26 | — | — | US | disclosed |
| EP-2320910-A1 | CHEMICAL COMPOUNDS AND USES | GlaxoSmithKline LLC (US) | 2011-05-18 | — | — | EP | disclosed |
| WO-2010014593-A1 | CHEMICAL COMPOUNDS AND USES | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-04 | — | — | WO | disclosed |