Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.32 |
| ▸ | CES1 | P23141 | 1/20 | 0.32 |
| ▸ | TTR | P02766 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA4 | P22748 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL177479 | 0.79 | CES2 (0.42) | KDM4ECES2CES1CA1CA2 | |
| SCHEMBL1318412 | 0.78 | KDM4E (0.41) | ERN1KDM4E | |
| SCHEMBL28703625 | 0.77 | CES2 (0.40) | KDM4ECES2CES1CA1CA2 | |
| SCHEMBL29825907 | 0.75 | KDM4E (0.48) | ERN1KDM4ETTRCA1CA2 | |
| SCHEMBL155586 | 0.75 | KDM4E (0.48) | ERN1KDM4ETTRCA1CA2 | |
| SCHEMBL31559956 | 0.75 | KDM4E (0.48) | ERN1KDM4ETTRCA1CA2 | |
| SCHEMBL18384417 | 0.75 | KDM4E (0.48) | ERN1KDM4ETTRCA1CA2 | |
| SCHEMBL152523 | 0.75 | KDM4E (0.48) | ERN1KDM4ETTRCA1CA2 | |
| SCHEMBL34466630 | 0.74 | ERN1 (0.47) | ERN1CA1 | |
| SCHEMBL585592 | 0.73 | ERN1 (0.61) | ERN1KDM4ECES2CES1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016146651-A1 | MACROCYCLIC ACTIVIN-LIKE RECEPTOR KINASE INHIBITORS | ONCODESIGN SA (FR) | 2016-09-22 | — | — | WO | disclosed |