Known targets — ChEMBL curated mechanism
FGFR1FGFR2FGFR3FGFR4FLT1FLT4KDRPDGFRAPDGFRB
The experimentally established mechanism targets of 2-Mercaptoethanol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 2-Mercaptoethanol SCHEMBL6385165 | 0.95 | PTGS1 (0.43) | PTGS1PDE4AALDH1A1KDM4EGAA | |
| SCHEMBL626439 | 0.93 | ALDH1A1 (0.41) | ALDH1A1KDM4EGAACHRM2CHRM1 | |
| Alcohol SCHEMBL7566185 | 0.89 | ALDH1A1 (0.41) | ALDH1A1KDM4EGAACHRM2CHRM1 | |
| SCHEMBL9790 | 0.87 | ALDH1A1 (0.45) | ALDH1A1KDM4EGAACHRM2CHRM1 | |
| SCHEMBL2417 | 0.87 | ALDH1A1 (0.45) | ALDH1A1KDM4EGAACHRM2CHRM1 | |
| SCHEMBL2229127 | 0.87 | ALDH1A1 (0.45) | ALDH1A1KDM4EGAACHRM2CHRM1 | |
| SCHEMBL20504316 | 0.86 | ALDH1A1 (0.40) | ALDH1A1KDM4EGAACHRM2CHRM1 | |
| SCHEMBL21752843 | 0.85 | ALDH1A1 (0.43) | ALDH1A1KDM4EGAACHRM2CHRM1 | |
| SCHEMBL21752977 | 0.85 | ALDH1A1 (0.43) | ALDH1A1KDM4EGAACHRM2CHRM1 | |
| Sulfuric Acid SCHEMBL6545396 | 0.85 | ALDH1A1 (0.43) | ALDH1A1KDM4EGAACHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110111495-A1 | CONCENTRATED MEDIUM AND ITS USAGE | SHANGHAI CP GUOJIAN PHARMACEUTICAL CO. LTD (CN) | 2011-05-12 | — | — | US | claimed |
| US-20110111495-A1 | CONCENTRATED MEDIUM AND ITS USAGE | SHANGHAI CP GUOJIAN PHARMACEUTICAL CO. LTD (CN) | 2011-05-12 | — | — | US | disclosed |