Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 9/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 9/20 | 0.40 |
| ▸ | ITGA5 | P08648 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18092081 | 0.96 | GABRA5 (0.40) | GABRA5GABRA1ITGA5 | |
| SCHEMBL285448 | 0.87 | GABRA5 (0.43) | GABRA5GABRA1ITGA5 | |
| SCHEMBL18092034 | 0.85 | GABRA5 (0.35) | GABRA5GABRA1ITGA5 | |
| SCHEMBL18091964 | 0.82 | L3MBTL1 (0.36) | GABRA5GABRA1 | |
| SCHEMBL285753 | 0.81 | GABRA5 (0.42) | GABRA5GABRA1ITGA5 | |
| SCHEMBL18092065 | 0.81 | GABRA5 (0.36) | GABRA5GABRA1ITGA5 | |
| SCHEMBL15252329 | 0.80 | GABRA5 (0.44) | GABRA5GABRA1ITGA5 | |
| SCHEMBL285524 | 0.80 | CHRM4 (0.41) | GABRA5GABRA1ITGA5 | |
| SCHEMBL18092050 | 0.79 | GABRA5 (0.35) | GABRA5 | |
| SCHEMBL18091974 | 0.79 | GABRA5 (0.35) | GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427459-B1 | ISOXAZOLE-THIAZOLE DERIVATIVES AS GABA A RECEPTOR INVERSE AGONISTS FOR USE IN THE TREATMENT OF COGNITIVE DISORDERS | HOFFMANN LA ROCHE (CH) | 2016-09-28 | — | — | EP | claimed |