Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18092077 | 0.85 | L3MBTL1 (0.33) | L3MBTL1ALDH1A1GABRA5 | |
| SCHEMBL18092080 | 0.84 | L3MBTL1 (0.34) | L3MBTL1ALDH1A1 | |
| SCHEMBL286158 | 0.84 | TLR8 (0.35) | TLR8TLR7L3MBTL1ALDH1A1GABRA5 | |
| SCHEMBL18091987 | 0.82 | L3MBTL1 (0.33) | L3MBTL1ALDH1A1 | |
| SCHEMBL18091966 | 0.81 | L3MBTL1 (0.33) | L3MBTL1ALDH1A1GABRA5 | |
| SCHEMBL18091968 | 0.81 | L3MBTL1 (0.33) | L3MBTL1ALDH1A1GABRA5 | |
| SCHEMBL18092040 | 0.81 | L3MBTL1 (0.33) | L3MBTL1ALDH1A1GABRA5 | |
| SCHEMBL18092016 | 0.80 | GABRA5 (0.49) | ALDH1A1GABRA5 | |
| SCHEMBL18092065 | 0.79 | GABRA5 (0.36) | GABRA5 | |
| SCHEMBL18092034 | 0.79 | GABRA5 (0.35) | L3MBTL1GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427459-B1 | ISOXAZOLE-THIAZOLE DERIVATIVES AS GABA A RECEPTOR INVERSE AGONISTS FOR USE IN THE TREATMENT OF COGNITIVE DISORDERS | HOFFMANN LA ROCHE (CH) | 2016-09-28 | — | — | EP | claimed |