Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.37 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.37 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CLK1 | P49759 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1809791 | 0.81 | TP53 (0.47) | KDM4EEGLN1L3MBTL1LIMK1MAP2K1 | |
| SCHEMBL1810754 | 0.79 | EGLN1 (0.73) | EGLN1 | |
| SCHEMBL1810830 | 0.77 | EGLN1 (0.46) | KDM4EEGLN1L3MBTL1LIMK1ALDH1A1 | |
| SCHEMBL4858574 | 0.74 | LIMK1 (0.50) | KDM4EEGLN1L3MBTL1LIMK1MAP2K1 | |
| SCHEMBL967939 | 0.74 | FEN1 (0.55) | KDM4EEGLN1L3MBTL1ALDH1A1 | |
| SCHEMBL1810341 | 0.72 | EGLN1 (0.40) | KDM4EEGLN1L3MBTL1ALDH1A1LCK | |
| SCHEMBL1810167 | 0.72 | EGLN1 (0.40) | KDM4EEGLN1L3MBTL1ALDH1A1LMNA | |
| SCHEMBL1974306 | 0.72 | LCK (0.36) | KDM4EEGLN1L3MBTL1ALDH1A1LMNA | |
| SCHEMBL22866720 | 0.72 | KDM4E (0.48) | KDM4EEGLN1L3MBTL1LIMK1MAP2K1 | |
| SCHEMBL29560195 | 0.72 | KDM4E (0.48) | KDM4EEGLN1L3MBTL1LIMK1MAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011056725-A1 | PYRIDINE DERIVATIVES AND METHODS OF USE THEREOF | CRYSTALGENOMICS, INC. (KR) | 2011-05-12 | — | — | WO | disclosed |