Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 1/20 | 0.43 |
| ▸ | FAP | Q12884 | 1/20 | 0.42 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.40 |
| ▸ | GBA1 | P04062 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | EDNRA | P25101 | 1/20 | 0.38 |
| ▸ | TGM2 | P21980 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18093554 | 1.00 | PREP (0.43) | PREPFAPHTR4GBA1EPHX2 | |
| SCHEMBL9226973 | 0.82 | PREP (0.52) | PREPHTR4GBA1EPHX2EDNRA | |
| SCHEMBL7292745 | 0.81 | PREP (0.49) | PREPHTR4GBA1EPHX2HDAC4 | |
| Hydrochloric Acid SCHEMBL7296249 | 0.81 | PREP (0.52) | PREPHTR4GBA1EPHX2TGM2 | |
| Hydrochloric Acid SCHEMBL7296408 | 0.81 | PREP (0.52) | PREPHTR4GBA1EPHX2TGM2 | |
| Hydrochloric Acid SCHEMBL7303396 | 0.72 | PREP (0.40) | PREP | |
| Hydrochloric Acid SCHEMBL7296222 | 0.72 | PREP (0.40) | PREP | |
| SCHEMBL29596119 | 0.72 | TSHR (0.42) | PREPFAPPOLB | |
| SCHEMBL7295354 | 0.71 | TGM2 (0.50) | PREPFAPTGM2 | |
| SCHEMBL23659223 | 0.69 | CYP3A4 (0.52) | FAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9809586-B2 | Inhibitors of collagen prolyl 4-hydroxylase | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2017-11-07 | — | — | US | disclosed |
| WO-2016160706-A1 | INHIBITORS OF COLLAGEN PROLYL 4-HYDROXYLASE | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2016-10-06 | — | — | WO | disclosed |
| US-20160280701-A1 | INHIBITORS OF COLLAGEN PROLYL 4-HYDROXYLASE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160280701-A1 | INHIBITORS OF COLLAGEN PROLYL 4-HYDROXYLASE | P4HA1, EGLN3, P4HTM | PREP 141/4885FAP 1167/4885HTR4 720/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.