Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | CASP7 | P55210 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6479440 | 0.84 | KDM4E (0.49) | HSD17B10KDM4ENPC1MAPTRAB9A | |
| SCHEMBL13377057 | 0.80 | HSD17B10 (0.53) | HSD17B10KDM4ENPC1MAPTALDH1A1 | |
| SCHEMBL21863415 | 0.80 | HSD17B10 (0.51) | HSD17B10KDM4ENPC1MAPTRAB9A | |
| SCHEMBL24654981 | 0.79 | HSD17B10 (0.47) | HSD17B10KDM4ENPC1MAPTRAB9A | |
| SCHEMBL10012248 | 0.79 | HSD17B10 (0.50) | HSD17B10KDM4ENPC1MAPTRAB9A | |
| SCHEMBL21849003 | 0.78 | HSD17B10 (0.46) | HSD17B10KDM4ENPC1MAPTRAB9A | |
| SCHEMBL7976886 | 0.76 | KMT2A (0.63) | HSD17B10KDM4ENPC1RAB9AALDH1A1 | |
| SCHEMBL13050157 | 0.75 | KDM4E (0.49) | HSD17B10KDM4ENPC1MAPTRAB9A | |
| SCHEMBL266148 | 0.75 | KMT2A (0.58) | HSD17B10KDM4ENPC1MAPTRAB9A | |
| SCHEMBL3050995 | 0.75 | ALDH1A1 (0.55) | HSD17B10KDM4ENPC1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160280685-A1 | SUBSTITUTED PYRIDINE AND PYRAZINE BMI-1 INHIBITORS | PTC THERAPEUTICS, INC. | 2016-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160280685-A1 | SUBSTITUTED PYRIDINE AND PYRAZINE BMI-1 INHIBITORS | BMI1, BAZ2A, BAZ2B | HSD17B10 2940/4885KDM4E 102/4885NPC1 3521/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.