Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18012101 | 1.00 | MAPT (0.31) | MAPT | |
| SCHEMBL18012102 | 0.87 | PTPN1 (0.33) | MAPT | |
| SCHEMBL16615709 | 0.87 | PTPN1 (0.33) | MAPT | |
| SCHEMBL18101204 | 0.83 | PTPN1 (0.32) | MAPT | |
| SCHEMBL12640536 | 0.77 | PTGS2 (0.38) | — | |
| SCHEMBL16615681 | 0.76 | TSHR (0.33) | MAPT | |
| SCHEMBL15121071 | 0.76 | HDAC3 (0.42) | MAPT | |
| SCHEMBL10000059 | 0.75 | ALOX15 (0.46) | MAPT | |
| SCHEMBL16137785 | 0.75 | — | — | |
| SCHEMBL10000060 | 0.74 | HPGD (0.40) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016187788-A1 | FUSED TRICYCLIC HETEROCYCLIC COMPOUNDS USEFUL FOR TREATING HIV INFECTION | MERCK SHARP & DOHME CORP. (US) | 2016-12-01 | — | — | WO | disclosed |
| WO-2016191239-A1 | FUSED TRICYCLIC HETEROCYCLIC COMPOUNDS USEFUL FOR TREATING HIV INFECTION | MERCK SHARP & DOHME CORP. (US) | 2016-12-01 | — | — | WO | disclosed |
| WO-2016154527-A1 | PHOSPHATE-SUBSTITUTED QUINOLIZINE DERIVATIVES USEFUL AS HIV INTEGRASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-09-29 | — | — | WO | disclosed |