SCHEMBL181015

SCHEMBL181015

Brc1ccc(C2CCNCC2)cc1

nearest known ligand 0.61

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
SLC18A3 Q16572 1/20 0.61
SIGMAR1 Q99720 1/20 0.61
HTR2C P28335 8/20 0.57
QDPR P09417 1/20 0.52
HTR3A P46098 1/20 0.48
MAPT P10636 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
P2RY14 Q15391 1/20 0.41
KDM1A O60341 1/20 0.41
MAOA P21397 1/20 0.41
MAOB P27338 1/20 0.41
NAMPT P43490 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL1129031 0.98 SLC18A3 (0.59) SLC18A3SIGMAR1HTR2CQDPRHTR3A
Iodide SCHEMBL16799291 0.98 SLC18A3 (0.59) SLC18A3SIGMAR1HTR2CQDPRHTR3A
SCHEMBL25788737 0.89 SLC18A3 (0.50) SLC18A3SIGMAR1HTR2CQDPRHTR3A
Alcohol SCHEMBL27595503 0.89 SLC18A3 (0.50) SLC18A3SIGMAR1HTR2CQDPRHTR3A
SCHEMBL12640684 0.87 HTR3A (0.66) SLC18A3SIGMAR1HTR2CHTR3A
SCHEMBL1002475 0.87 HTR3A (0.66) SLC18A3SIGMAR1HTR2CHTR3A
Hydrochloric Acid SCHEMBL15300834 0.85 HTR3A (0.63) SLC18A3SIGMAR1HTR2CHTR3A
Pyrrolidine SCHEMBL9026279 0.84 CYP2D6 (0.45) SLC18A3SIGMAR1HTR2CQDPRHTR3A
Pivalate SCHEMBL25318872 0.83 SIGMAR1 (0.49) SLC18A3SIGMAR1HTR2CQDPRP2RY14
SCHEMBL265495 0.83 KDM1A (0.48) HTR2CMAPTSMN1; SMN2TDP1KDM1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 350 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116768826-B Rupestonic acid amide derivative containing nitrogen heterocycle, and preparation method and application thereof 中国科学院新疆理化技术研究所 2025-05-27 CN claimed
CN-119841766-A Preparation method and application of glutarimide compound 上海凌凯科技股份有限公司 2025-04-18 CN claimed
CN-116768826-A Rupestonic acid amide derivative containing nitrogen heterocycle, and preparation method and application thereof 中国科学院新疆理化技术研究所 2023-09-19 CN claimed
CN-110590738-B Synthetic method of 3, 6-dimethyl-1-secondary amino-7-cyano-8-hydroxyisoquinoline compound 温州大学 2022-03-01 CN claimed
CN-110590738-A Synthetic method of 3, 6-dimethyl-1-secondary amino-7-cyano-8-hydroxyisoquinoline compound 温州大学 2019-12-20 CN claimed
US-20260124309-A1 STAT6 DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS INC (US) 2026-05-07 US disclosed
EP-4731223-A1 MORPHOLINE AND 1,4-OXAZEPANE COMPOUNDS AND ITS USE IN THERAPY Universitat De Barcelona (ES) 2026-04-29 EP disclosed
US-12552801-B2 Indazole derivatives HOFFMANN-LA ROCHE INC. (US) 2026-02-17 US disclosed
EP-4676476-A1 INHIBITORS OF TDP-43 AND TAU AGGREGATION Aquinnah Pharmaceuticals, Inc. (US) 2026-01-14 EP disclosed
EP-4676922-A1 BIFUNCTIONAL COMPOUNDS CAPABLE OF DEGRADING ANDROGEN RECEPTORS Astrazeneca AB (SE) 2026-01-14 EP disclosed
US-12479849-B2 EGFR inhibitors for the treatment of cancer HOFFMANN-LA ROCHE INC. (US) 2025-11-25 US disclosed
EP-4647431-A1 COMPOUND AND METHOD FOR TARGETED DEGRADATION OF ANDROGEN RECEPTOR Gan & lee Pharm Co., Ltd. (CN) 2025-11-12 EP disclosed
EP-1188747-A1 PHENOXYPROPYLAMINE COMPOUNDS Mitsubishi Pharma Corporation (JP) 2002-03-20 EP disclosed
US-6355642-B1 PSYCHOLOGICAL DISORDERS AND BRAIN DISORDERS MEIJI SEIKA KAISHA, LTD. (JP) 2002-03-12 US disclosed
US-6303593-B1 FOR THERAPY HUMAN IMMUNODEFICIENCY VIRUS INFECTION, AQUIRED IMMUNODEFICIENCY SYNDROME (AIDS), INFLAMMATORY AND IMMUNOREGULATORY DISORDER OR DISEASE, ASTHMA, ALLERGIC RHINITIS, DERMATITIS, CONJUNCTIVITIS, ATHEROSCLEROSIS MERCK & CO., INC. 2001-10-16 US disclosed
WO-2000051608-A1 3-THIENYL AND 3-FURANYL PYRROLIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY MERCK & CO., INC. (US) 2000-09-08 WO disclosed
EP-0937715-A1 TETRAHYDROBENZINDOLE COMPOUNDS MEIJI SEIKA KAISHA LTD. (JP) 1999-08-25 EP disclosed
US-5489599-A FUNGICIDES SHELL RESEARCH LIMITED (GB) 1996-02-06 US disclosed
WO-1992012130-A1 PIPERIDINE DERIVATIVES SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V. (NL) 1992-07-23 WO disclosed
EP-0494717-A1 Piperidine derivatives SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) 1992-07-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260124309-A1 STAT6 DEGRADERS AND USES THEREOF STAT6, NCOR2, NCOR1 SLC18A3 4755/4885SIGMAR1 47/4885HTR2C 751/4885
US-12552801-B2 Indazole derivatives EGFR, ABL1, ERBB3 SLC18A3 2158/4885SIGMAR1 183/4885HTR2C 327/4885
US-12479849-B2 EGFR inhibitors for the treatment of cancer EGFR, ERBB2, ERBB3 SLC18A3 4340/4885SIGMAR1 1435/4885HTR2C 916/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.