Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAOX | Q6QHF9 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22096301 | 0.84 | KDM4E (0.42) | KDM4ESMN1; SMN2LMNAL3MBTL1PDE4A | |
| SCHEMBL22096293 | 0.84 | MEN1 (0.48) | KDM4ELMNAL3MBTL1PDE4ATDP1 | |
| SCHEMBL10337937 | 0.84 | KDM4E (0.54) | KDM4ESMN1; SMN2LMNAL3MBTL1PDE4A | |
| SCHEMBL22096294 | 0.80 | KDM4E (0.39) | KDM4ELMNAL3MBTL1PDE4ATDP1 | |
| SCHEMBL11413052 | 0.80 | KDM4E (0.56) | KDM4EMAPK1HIF1ASMN1; SMN2LMNA | |
| SCHEMBL12510383 | 0.80 | KDM4E (0.56) | KDM4EMAPK1HIF1ASMN1; SMN2LMNA | |
| SCHEMBL13280858 | 0.80 | KDM4E (0.56) | KDM4EMAPK1HIF1ASMN1; SMN2LMNA | |
| SCHEMBL6674457 | 0.80 | KDM4E (0.56) | KDM4EMAPK1HIF1ASMN1; SMN2LMNA | |
| SCHEMBL5707586 | 0.80 | KDM4E (0.56) | KDM4EMAPK1HIF1ASMN1; SMN2LMNA | |
| SCHEMBL18102799 | 0.80 | ZDHHC20 (0.42) | KDM4EMAPK1LMNAL3MBTL1PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10683379-B2 | Polymers, hydrogels, and uses thereof | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2020-06-16 | — | — | US | disclosed |
| US-20160280827-A1 | POLYMERS, HYDROGELS, AND USES THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 2016-09-29 | — | — | US | disclosed |
| WO-2016154317-A2 | POLYMERS, HYDROGELS, AND USES THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2016-09-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10683379-B2 | Polymers, hydrogels, and uses thereof | BOLA2; BOLA2B, PARG, BRAP | PAOX 317/4885KDM4E 4052/4885MAPK1 2714/4885 |
| US-20160280827-A1 | POLYMERS, HYDROGELS, AND USES THEREOF | BOLA2; BOLA2B, PARG, BRAP | PAOX 317/4885KDM4E 4052/4885MAPK1 2714/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.