Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 14/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 14/20 | 1.00 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 1.00 |
| ▸ | NSD2 | O96028 | 1/20 | 1.00 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 1.00 |
| ▸ | POLB | P06746 | 8/20 | 0.73 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.73 |
| ▸ | MAPT | P10636 | 4/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.66 |
| ▸ | LMNA | P02545 | 2/20 | 0.66 |
| ▸ | HPGD | P15428 | 1/20 | 0.66 |
| ▸ | RAB9A | P51151 | 1/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.65 |
| ▸ | CASP3 | P42574 | 2/20 | 0.65 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.65 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.65 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.65 |
| ▸ | ATM | Q13315 | 2/20 | 0.65 |
| ▸ | GAA | P10253 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19999130 | 0.85 | MEN1 (0.74) | MEN1KMT2AHSP90AA1NSD2APOBEC3G | |
| SCHEMBL23752553 | 0.85 | MEN1 (1.00) | MEN1KMT2AHSP90AA1NSD2APOBEC3G | |
| SCHEMBL23752554 | 0.85 | MEN1 (1.00) | MEN1KMT2AHSP90AA1NSD2APOBEC3G | |
| SCHEMBL18102937 | 0.84 | MEN1 (0.73) | MEN1KMT2AHSP90AA1NSD2APOBEC3G | |
| SCHEMBL18103095 | 0.84 | MEN1 (0.72) | MEN1KMT2AHSP90AA1NSD2APOBEC3G | |
| SCHEMBL18102872 | 0.83 | MEN1 (0.71) | MEN1KMT2AHSP90AA1NSD2APOBEC3G | |
| SCHEMBL6886400 | 0.82 | KMT2A (0.70) | MEN1KMT2AHSP90AA1NSD2APOBEC3G | |
| SCHEMBL6886396 | 0.82 | KMT2A (0.70) | MEN1KMT2AHSP90AA1NSD2APOBEC3G | |
| SCHEMBL18103009 | 0.82 | MEN1 (0.69) | MEN1KMT2AHSP90AA1NSD2APOBEC3G | |
| SCHEMBL5472001 | 0.81 | MEN1 (0.69) | MEN1KMT2AHSP90AA1NSD2APOBEC3G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016154255-A1 | INHIBITORS OF THE NOTCH TRANSCRIPTIONAL ACTIVATION COMPLEX AND METHODS FOR USE OF THE SAME | UNIVERSITY OF MIAMI (US) | 2016-09-29 | — | — | WO | disclosed |