Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.72 |
| ▸ | NSD2 | O96028 | 1/20 | 0.72 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.72 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.72 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | IDE | P14735 | 1/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.54 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.54 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.54 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18102872 | 0.91 | MEN1 (0.71) | MEN1KMT2ANSD2HSP90AA1APOBEC3G | |
| SCHEMBL19999128 | 0.85 | PDE4B (0.62) | MEN1KMT2ANSD2HSP90AA1APOBEC3G | |
| SCHEMBL8205466 | 0.85 | PDE4B (0.62) | MEN1KMT2ANSD2HSP90AA1APOBEC3G | |
| SCHEMBL8205465 | 0.85 | PDE4B (0.62) | MEN1KMT2ANSD2HSP90AA1APOBEC3G | |
| SCHEMBL18102937 | 0.85 | MEN1 (0.73) | MEN1KMT2ANSD2HSP90AA1APOBEC3G | |
| SCHEMBL18103009 | 0.85 | MEN1 (0.69) | MEN1KMT2ANSD2HSP90AA1APOBEC3G | |
| SCHEMBL18103012 | 0.84 | MEN1 (1.00) | MEN1KMT2ANSD2HSP90AA1APOBEC3G | |
| SCHEMBL18103013 | 0.84 | MEN1 (0.68) | MEN1KMT2ANSD2HSP90AA1APOBEC3G | |
| SCHEMBL18103010 | 0.84 | MEN1 (0.68) | MEN1KMT2ANSD2HSP90AA1APOBEC3G | |
| SCHEMBL6886396 | 0.83 | KMT2A (0.70) | MEN1KMT2ANSD2HSP90AA1APOBEC3G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016154255-A1 | INHIBITORS OF THE NOTCH TRANSCRIPTIONAL ACTIVATION COMPLEX AND METHODS FOR USE OF THE SAME | UNIVERSITY OF MIAMI (US) | 2016-09-29 | — | — | WO | disclosed |