Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | PIM1 | P11309 | 1/20 | 0.55 |
| ▸ | KDM1A | O60341 | 12/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.53 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.53 |
| ▸ | PRNP | P04156 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.53 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.53 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL48846 | 0.97 | KDM4E (0.62) | KDM4ECYP2C9HPGDDUSP3L3MBTL1 | |
| SCHEMBL30611012 | 0.97 | KDM4E (0.62) | KDM4ECYP2C9HPGDDUSP3L3MBTL1 | |
| SCHEMBL3774110 | 0.92 | KDM4E (0.58) | KDM4ECYP2C9HPGDDUSP3L3MBTL1 | |
| Pyrazine SCHEMBL9102227 | 0.90 | KDM4E (0.57) | KDM4ECYP2C9HPGDDUSP3L3MBTL1 | |
| SCHEMBL26597840 | 0.83 | PIM1 (0.57) | KDM4EL3MBTL1PIM1KDM1ASIGMAR1 | |
| SCHEMBL30115198 | 0.83 | MEN1 (0.58) | KDM4EHPGDL3MBTL1PIM1KDM1A | |
| SCHEMBL48681 | 0.83 | MEN1 (0.58) | KDM4EHPGDL3MBTL1PIM1KDM1A | |
| SCHEMBL30115197 | 0.83 | MEN1 (0.58) | KDM4EHPGDL3MBTL1PIM1KDM1A | |
| SCHEMBL48847 | 0.81 | MEN1 (0.57) | KDM4EHPGDL3MBTL1PIM1KDM1A | |
| SCHEMBL8444747 | 0.81 | MEN1 (0.57) | KDM4EHPGDL3MBTL1PIM1KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10000643-B1 | Waterborne corrosion resistant organic primer compositions | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 2018-06-19 | — | — | US | disclosed |
| US-9458329-B1 | Corrosion protection by coatings that include organic additives | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 2016-10-04 | — | — | US | disclosed |