SCHEMBL48847

SCHEMBL48847

O=S(=O)(O)CCCN1c2ccccc2Sc2ccccc21.[NaH]

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 5/20 0.57
KMT2A Q03164 5/20 0.57
MAPT P10636 4/20 0.57
MMP13 P45452 2/20 0.57
POLB P06746 2/20 0.57
PIM1 P11309 1/20 0.55
ALOX15 P16050 3/20 0.55
TP53 P04637 2/20 0.55
TDP1 Q9NUW8 2/20 0.55
KDM4E B2RXH2 2/20 0.55
USP2 O75604 1/20 0.55
CYP3A4 P08684 1/20 0.55
MAPK1 P28482 1/20 0.55
RAD52 P43351 1/20 0.55
L3MBTL1 Q9Y468 1/20 0.55
LMNA P02545 3/20 0.54
KDM1A O60341 9/20 0.53
SIGMAR1 Q99720 2/20 0.53
SLC22A1 O15245 1/20 0.53
PRNP P04156 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30115198 0.98 MEN1 (0.58) MEN1KMT2AMAPTMMP13POLB
SCHEMBL30115197 0.98 MEN1 (0.58) MEN1KMT2AMAPTMMP13POLB
SCHEMBL48681 0.98 MEN1 (0.58) MEN1KMT2AMAPTMMP13POLB
SCHEMBL8444747 0.97 MEN1 (0.57) MEN1KMT2AMAPTMMP13POLB
SCHEMBL3774114 0.95 PIM1 (0.58) MEN1KMT2AMAPTMMP13POLB
SCHEMBL49291 0.94 PIM1 (0.59) MEN1KMT2AMAPTMMP13POLB
SCHEMBL31384188 0.94 PIM1 (0.59) MEN1KMT2AMAPTMMP13POLB
SCHEMBL10023985 0.89 MEN1 (0.58) MEN1KMT2AMAPTMMP13POLB
SCHEMBL9102418 0.87 MAPT (0.53) MEN1KMT2AMAPTMMP13POLB
SCHEMBL9102304 0.87 MAPT (0.64) MEN1KMT2AMAPTMMP13POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2405016-B1 Method for increasing and regulating light emission from a chemiluminescent reaction CYANAGEN SRL (IT) 2018-03-21 EP claimed
US-9632034-B2 Fluorogenic and chromogenic substrate LI-COR, INC. (US) 2017-04-25 US claimed
US-20160266045-A1 FLUOROGENIC AND CHROMOGENIC SUBSTRATE LI-COR, INC. (US) 2016-09-15 US claimed
US-9040252-B2 Method for increasing and regulating light emission from a chemiluminescent reaction CYANAGEN S.R.L. (IT) 2015-05-26 US claimed
EP-1950207-B1 Preparation of high purity phenothiazine n-alkylsulfonates and their use in chemiluminescent assays for the measurement of peroxidase activity CYANAGEN SRL (IT) 2012-06-20 EP claimed
US-8129136-B2 Kit for performing an assay CYANAGEN SRL (IT) 2012-03-06 US claimed
US-20120009603-A1 METHOD FOR INCREASING AND REGULATING LIGHT EMISSION FROM A CHEMILUMINESCENT REACTION CYANAGEN S.R.L. (IT) 2012-01-12 US claimed
EP-2405016-A1 Method for increasing and regulating light emission from a chemiluminescent reaction Cyanagen Srl (IT) 2012-01-11 EP claimed
EP-1962095-B1 Method for increasing light emission from a chemiluminescent reaction CYANAGEN SRL (IT) 2011-06-15 EP claimed
US-20110053200-A1 Method for increasing light emission from a chemiluminescent reaction CYANAGEN SRL (IT) 2011-03-03 US claimed
US-7855287-B2 Preparation of high purity phenothiazine N-alkylsulfonates and their use in chemiluminescent assays for the measurement of peroxidase activity CYANAGEN SRL (IT) 2010-12-21 US claimed
US-7803573-B2 Method for increasing light emission from a chemiluminescent reaction CYANAGEN SRL (IT) 2010-09-28 US claimed
US-20080241868-A1 Method for increasing light emission from a chemiluminescent reaction CYANAGEN SRL (IT) 2008-10-02 US claimed
EP-1962095-A1 Method for increasing light emission from a chemiluminescent reaction Cyanagen Srl (IT) 2008-08-27 EP claimed
EP-1950207-A1 Preparation of high purity phenothiazine n-alkylsulfonates and their use in chemiluminescent assays for the measurement of peroxidase activity Cyanagen Srl (IT) 2008-07-30 EP claimed
US-20080176251-A1 Preparation of high purity phenothiazine N-alkylsulfonates and their use in chemiluminescent assays for the measurement of peroxidase acitivity CYANAGEN SRL (IT) 2008-07-24 US claimed
US-5171668-A Measuring light emitted from contacting (iso)luminol, peroxide, peroxidase activity enhancer, such as indoanilines, phenolindophenol and N-methylphenothiazine, with labeled peroxidase antibody-antigen complex FUJIREBIO INC. (JP) 1992-12-15 US claimed
JP-11313697-A None JP disclosed
US-5171668-A Measuring light emitted from contacting (iso)luminol, peroxide, peroxidase activity enhancer, such as indoanilines, phenolindophenol and N-methylphenothiazine, with labeled peroxidase antibody-antigen complex FUJIREBIO INC. (JP) 1992-12-15 US disclosed
EP-0361470-A2 Method for the chemiluminescence assay of the activity of peroxidase FUJIREBIO INC. (JP) 1990-04-04 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080176251-A1 Preparation of high purity phenothiazine N-alkylsulfonates and their use in chemiluminescent assays for the measurement of peroxidase acitivity LPO, ARSA, SULT1E1 MEN1 3072/4885KMT2A 3382/4885MAPT 4772/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.