Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.74 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.74 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.74 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.74 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.74 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.67 |
| ▸ | HTR6 | P50406 | 8/20 | 0.64 |
| ▸ | HTT | P42858 | 4/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1842067 | 0.86 | MAPT (0.72) | MAPTCYP1A2CYP2C9CYP2C19NPSR1 | |
| SCHEMBL12684789 | 0.85 | MAPT (0.67) | MAPTCYP1A2CYP2C9CYP2C19NPSR1 | |
| SCHEMBL12684788 | 0.83 | MAPT (0.70) | MAPTCYP1A2CYP2C9CYP2C19NPSR1 | |
| SCHEMBL2390380 | 0.82 | MAPT (0.63) | MAPTCYP1A2CYP2C9CYP2C19NPSR1 | |
| SCHEMBL1846387 | 0.82 | MAPT (0.66) | MAPTCYP1A2CYP2C9CYP2C19NPSR1 | |
| SCHEMBL2481061 | 0.81 | MAPT (0.86) | MAPTCYP1A2CYP2C9CYP2C19NPSR1 | |
| SCHEMBL1847175 | 0.81 | SIRT6 (1.00) | MAPTCYP1A2CYP2C9CYP2C19NPSR1 | |
| SCHEMBL1845533 | 0.79 | MAPT (0.74) | MAPTCYP1A2CYP2C9CYP2C19NPSR1 | |
| SCHEMBL1844704 | 0.78 | HTR6 (1.00) | MAPTCYP1A2CYP2C9CYP2C19NPSR1 | |
| SCHEMBL2389029 | 0.78 | MAPT (0.80) | MAPTCYP1A2CYP2C9CYP2C19NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160283652-A1 | METHODS FOR IDENTIFYING INHIBITORS OF AMYLOID PROTEIN AGGREGATION | TREVENTIS CORPORATION (US) | 2016-09-29 | — | — | US | disclosed |