Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | C1R | P00736 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 2/20 | 0.33 |
| ▸ | CCNK | O75909 | 1/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | CDK7 | P50613 | 1/20 | 0.32 |
| ▸ | CCNH | P51946 | 1/20 | 0.32 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.32 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25380543 | 0.77 | IDO1 (0.45) | BACE1CYP1A2RAB9AKDM4EMAPT | |
| SCHEMBL26441992 | 0.77 | MAPT (0.43) | BACE1CYP1A2NPC1RAB9AC1R | |
| SCHEMBL2882632 | 0.77 | LMNA (0.40) | PDGFRBPDGFRAADORA2ACYP1A2PDE10A | |
| SCHEMBL23002965 | 0.77 | MAPT (0.41) | PDGFRBPDGFRAADORA2APDE10ANPC1 | |
| SCHEMBL558627 | 0.77 | ADORA2A (0.49) | PDGFRBPDGFRAADORA2ACYP1A2RAB9A | |
| SCHEMBL31116662 | 0.74 | NPC1 (0.57) | PDGFRBPDGFRACYP1A2NPC1RAB9A | |
| SCHEMBL10220808 | 0.73 | CCNE2 (0.36) | PDGFRBPDGFRAPDE10ARAB9ACCNA2 | |
| SCHEMBL10272460 | 0.73 | PDE10A (0.40) | PDGFRBPDGFRAADORA2APDE10APDE7A | |
| SCHEMBL26090878 | 0.72 | BACE1 (0.41) | PDGFRBPDGFRABACE1ADORA2ACYP1A2 | |
| SCHEMBL15638042 | 0.69 | ALDH1A1 (0.48) | CYP1A2CYP3A4CYP2C19NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2321296-A1 | SUBSTITUTED 5-AMINOPYRAZOLES AND USE THEREOF | Bayer Schering Pharma Aktiengesellschaft (DE) | 2011-05-18 | — | — | EP | disclosed |
| WO-2010020363-A1 | SUBSTITUTED 5-AMINOPYRAZOLES AND USE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-02-25 | — | — | WO | disclosed |