Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | APAF1 | O14727 | 1/20 | 0.43 |
| ▸ | NSD2 | O96028 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1991256 | 0.71 | SMN1; SMN2 (0.61) | L3MBTL1SMN1; SMN2ALDH1A1TP53KDM4E | |
| SCHEMBL11277506 | 0.69 | SMN1; SMN2 (0.59) | L3MBTL1SMN1; SMN2ALDH1A1TP53KDM4E | |
| SCHEMBL9955648 | 0.69 | SMN1; SMN2 (0.44) | L3MBTL1SMN1; SMN2ALDH1A1TP53MAPT | |
| SCHEMBL7753780 | 0.68 | LMNA (0.52) | L3MBTL1SMN1; SMN2ALDH1A1TP53KDM4E | |
| SCHEMBL1992191 | 0.67 | SMN1; SMN2 (0.57) | L3MBTL1SMN1; SMN2ALDH1A1TP53KDM4E | |
| SCHEMBL1067810 | 0.66 | SMN1; SMN2 (0.55) | L3MBTL1SMN1; SMN2ALDH1A1TP53KDM4E | |
| SCHEMBL7386390 | 0.66 | SMN1; SMN2 (0.41) | L3MBTL1SMN1; SMN2ALDH1A1TP53MAPT | |
| SCHEMBL1070289 | 0.66 | SMN1; SMN2 (0.55) | L3MBTL1SMN1; SMN2ALDH1A1TP53KDM4E | |
| SCHEMBL11261641 | 0.66 | CA12 (0.50) | SMN1; SMN2ALDH1A1KDM4ECA12CA2 | |
| SCHEMBL6238026 | 0.66 | KDM4E (0.52) | L3MBTL1ALDH1A1TP53KDM4EAPAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2560963-B1 | PYRAZINE DERIVATIVES AS INHIBITORS OF THE ENZYME SCD-1 FOR THE TREATMENT OF CANCER DISEASES AND DIABETES | PF MEDICAMENT (FR) | 2016-10-05 | — | — | EP | disclosed |