SCHEMBL18106980

SCHEMBL18106980

CCCCCc1cc(-c2ccccc2)n[nH]1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.54
LMNA P02545 1/20 0.54
HCAR2 Q8TDS4 4/20 0.53
HCAR3 P49019 3/20 0.53
CYP11B1 P15538 1/20 0.49
CYP11B2 P19099 1/20 0.49
PDE10A Q9Y233 1/20 0.48
POLB P06746 1/20 0.47
RAB9A P51151 1/20 0.47
CYP1A2 P05177 1/20 0.47
CYP2D6 P10635 1/20 0.47
CYP19A1 P11511 1/20 0.47
CYP2C9 P11712 1/20 0.47
CYP2C19 P33261 1/20 0.47
COMT P21964 2/20 0.46
SPHK1 Q9NYA1 1/20 0.46
NR1H4 Q96RI1 1/20 0.46
MAPT P10636 1/20 0.46
HSD11B1 P28845 1/20 0.44
TP53 P04637 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2375495 0.88 L3MBTL1 (0.59) L3MBTL1LMNAHCAR2HCAR3CYP11B1
SCHEMBL11789235 0.87 HCAR2 (0.48) L3MBTL1LMNAHCAR2HCAR3CYP11B1
SCHEMBL27540721 0.86 HCAR2 (0.49) LMNAHCAR2HCAR3CYP11B1CYP11B2
SCHEMBL18010760 0.83 HCAR2 (0.60) HCAR2HCAR3COMTSPHK1
SCHEMBL2375250 0.82 LMNA (0.55) L3MBTL1LMNACYP11B1CYP11B2PDE10A
SCHEMBL1696565 0.81 L3MBTL1 (0.63) L3MBTL1LMNAHCAR2CYP11B1CYP11B2
SCHEMBL18813664 0.81 HCAR2 (0.48) L3MBTL1LMNAHCAR2HCAR3CYP11B1
SCHEMBL1312617 0.81 SPHK1 (0.52) HCAR2HCAR3RAB9ACYP1A2CYP2D6
SCHEMBL12117953 0.80 TSHR (0.55) L3MBTL1LMNAHCAR2HCAR3RAB9A
SCHEMBL17938569 0.79 HCAR2 (0.51) LMNAHCAR2HCAR3POLBRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2382197-B1 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR VERTEX PHARMA (US) 2016-10-05 EP disclosed