Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.57 |
| ▸ | CASP1 | P29466 | 1/20 | 0.57 |
| ▸ | CASP7 | P55210 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18106972 | 0.89 | MAPT (0.43) | MAPTMEN1KMT2AMAPK1ALOX15 | |
| SCHEMBL10139886 | 0.86 | MAPT (0.77) | MAPTMEN1KMT2AMAPK1ALOX15 | |
| SCHEMBL18106977 | 0.85 | LIMK2 (0.43) | MAPTMEN1KMT2AMAPK1ALOX15 | |
| SCHEMBL18106979 | 0.84 | TRPV1 (0.42) | MAPTMEN1KMT2AMAPK1ALOX15 | |
| SCHEMBL18106968 | 0.82 | MAPT (0.47) | MAPTMEN1KMT2AMAPK1ALOX15 | |
| SCHEMBL18106978 | 0.82 | BAZ2B (0.40) | MAPTMEN1KMT2AMAPK1ALOX15 | |
| SCHEMBL10139849 | 0.78 | MAPT (0.56) | MAPTMEN1KMT2AMAPK1ALOX15 | |
| SCHEMBL18106973 | 0.78 | MAPT (0.39) | MAPTMEN1KMT2AMAPK1ALOX15 | |
| Hydrochloric Acid SCHEMBL408968 | 0.78 | ALOX15 (0.55) | MAPTMEN1KMT2AMAPK1ALOX15 | |
| SCHEMBL18106970 | 0.77 | MAPT (0.42) | MAPTMEN1KMT2AMAPK1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2367822-B1 | TRICYCLIC AZAINDOLES | MERCK PATENT GMBH (DE) | 2016-10-05 | — | — | EP | claimed |