Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | CASP1 | P29466 | 2/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 5/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18106974 | 0.87 | EP300 (0.43) | TP53MKNK1KDR | |
| SCHEMBL18106971 | 0.86 | MAPT (0.42) | MAPTSMN1; SMN2ALOX15ALDH1A1HSD17B10 | |
| SCHEMBL407207 | 0.86 | MAPT (0.49) | MAPTKDM4EMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL18106969 | 0.84 | PRKAA2 (0.35) | MAPTPDGFRB | |
| SCHEMBL18106981 | 0.77 | MAPT (0.57) | MAPTKDM4EMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL407463 | 0.73 | MKNK1 (0.55) | MAPTMKNK1KDR | |
| SCHEMBL409364 | 0.72 | MAPT (0.55) | MAPTKDM4EALDH1A1MKNK1KDR | |
| SCHEMBL406798 | 0.71 | MAPT (0.45) | MAPTKDM4EMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL10139886 | 0.70 | MAPT (0.77) | MAPTKDM4EMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL18106977 | 0.68 | LIMK2 (0.43) | MAPTKDM4EMEN1KMT2AALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2367822-B1 | TRICYCLIC AZAINDOLES | MERCK PATENT GMBH (DE) | 2016-10-05 | — | — | EP | claimed |