Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 4/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | KCNJ6 | P48051 | 3/20 | 0.38 |
| ▸ | KCNJ3 | P48549 | 3/20 | 0.38 |
| ▸ | KCNJ5 | P48544 | 2/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 4/20 | 0.36 |
| ▸ | TP53 | P04637 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18111130 | 0.93 | IDO1 (0.48) | IDO1HDAC1KCNJ6KCNJ3KCNJ5 | |
| SCHEMBL18110865 | 0.92 | IDO1 (0.43) | IDO1HDAC1LTA4HSMN1; SMN2JAK2 | |
| SCHEMBL18110995 | 0.84 | IDO1 (0.47) | IDO1HDAC1KCNJ6KCNJ3KCNJ5 | |
| SCHEMBL18111884 | 0.83 | HDAC1 (0.42) | IDO1HDAC1LTA4HJAK2JAK1 | |
| SCHEMBL18110997 | 0.80 | LMNA (0.37) | IDO1HDAC1LMNANPC1RAB9A | |
| SCHEMBL18112731 | 0.77 | IDO1 (0.42) | IDO1HDAC1SMN1; SMN2JAK2JAK1 | |
| SCHEMBL18112096 | 0.77 | IDO1 (0.43) | IDO1LMNATP53MAPTALDH1A1 | |
| SCHEMBL18112202 | 0.76 | MEN1 (0.45) | IDO1LMNATP53SMN1; SMN2MAPT | |
| SCHEMBL18112002 | 0.75 | IDO1 (0.42) | IDO1LMNATP53NPC1RAB9A | |
| SCHEMBL18110704 | 0.75 | IDO1 (0.42) | IDO1LMNATP53NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10399933-B2 | Inhibitors of indoleamine-2,3-dioxygenase for the treatment of cancer | BRISTOL-MYERS SQUIBB COMPANY (US) | 2019-09-03 | — | — | US | disclosed |
| US-10399932-B2 | Inhibitors of indoleamine-2,3-dioxygenase for the treatment of cancer | BRISTOL-MYERS SQUIBB COMPANY (US) | 2019-09-03 | — | — | US | disclosed |
| US-10167254-B2 | IDO inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2019-01-01 | — | — | US | disclosed |
| US-20180072660-A1 | INHIBITORS OF INDOLEAMINE-2,3-DIOXYGENASE FOR THE TREATMENT OF CANCER | BRISTOL MYERS SQUIBB CO (US) | 2018-03-15 | — | — | US | disclosed |
| US-9790169-B2 | IDO inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-10-17 | — | — | US | disclosed |
| US-20170231999-A1 | IDO INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2017-08-17 | — | — | US | disclosed |
| US-20160289171-A1 | IDO INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2016-10-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10167254-B2 | IDO inhibitors | IDO1, IDO2, INMT | IDO1 1/4885HDAC1 67/4885KCNJ6 4129/4885 |
| US-20170231999-A1 | IDO INHIBITORS | IDO1, IDO2, INMT | IDO1 1/4885HDAC1 67/4885KCNJ6 4129/4885 |
| US-10399932-B2 | Inhibitors of indoleamine-2,3-dioxygenase for the treatment of cancer | IDO1, IDO2, INMT | IDO1 1/4885HDAC1 75/4885KCNJ6 3892/4885 |
| US-20180072660-A1 | INHIBITORS OF INDOLEAMINE-2,3-DIOXYGENASE FOR THE TREATMENT OF CANCER | IDO1, IDO2, INMT | IDO1 1/4885HDAC1 75/4885KCNJ6 3892/4885 |
| US-10399933-B2 | Inhibitors of indoleamine-2,3-dioxygenase for the treatment of cancer | IDO1, IDO2, INMT | IDO1 1/4885HDAC1 75/4885KCNJ6 3892/4885 |
| US-20160289171-A1 | IDO INHIBITORS | IDO1, IDO2, INMT | IDO1 1/4885HDAC1 67/4885KCNJ6 4129/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.