Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | LIMK1 | P53667 | 5/20 | 0.35 |
| ▸ | LIMK2 | P53671 | 5/20 | 0.35 |
| ▸ | TESK1 | Q15569 | 3/20 | 0.35 |
| ▸ | TESK2 | Q96S53 | 3/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20481494 | 0.86 | ADORA2A (0.46) | MEN1KMT2API4KBL3MBTL1 | |
| SCHEMBL20481613 | 0.82 | CFTR (0.35) | HTTSMN1; SMN2MEN1MAPTKMT2A | |
| SCHEMBL18113881 | 0.82 | PI4KB (0.36) | NPC1RAB9AHTTSMN1; SMN2TP53 | |
| SCHEMBL18113889 | 0.82 | ABL1 (0.37) | NPC1RAB9AHTTSMN1; SMN2TP53 | |
| SCHEMBL18113948 | 0.82 | POLQ (0.36) | NPC1RAB9AHTTSMN1; SMN2TP53 | |
| SCHEMBL18113854 | 0.81 | PI4KB (0.38) | NPC1RAB9AMEN1TP53MAPT | |
| SCHEMBL18113762 | 0.81 | PI4KB (0.39) | MEN1TP53KMT2API4KBKDM4E | |
| SCHEMBL18113853 | 0.81 | PIK3CG (0.36) | PIK3CG | |
| SCHEMBL18113960 | 0.81 | MALT1 (0.36) | NPC1RAB9AHTTSMN1; SMN2CHRM4 | |
| SCHEMBL20481549 | 0.81 | TP53 (0.37) | NPC1RAB9AHTTSMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180243298-A1 | TRPV3 MODULATORS | ABBVIE INC. | 2018-08-30 | — | — | US | claimed |
| WO-2016160938-A1 | N-(1,3-THIAZOL-2-YL)PYRIMIDINE-5-CARBOXAMIDES AS TRPV3 MODULATORS | ABBVIE INC. (US) | 2016-10-06 | — | — | WO | claimed |
| US-20180243298-A1 | TRPV3 MODULATORS | ABBVIE INC. | 2018-08-30 | — | — | US | disclosed |
| WO-2016160938-A1 | N-(1,3-THIAZOL-2-YL)PYRIMIDINE-5-CARBOXAMIDES AS TRPV3 MODULATORS | ABBVIE INC. (US) | 2016-10-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180243298-A1 | TRPV3 MODULATORS | TRPV3, TRPV1, TRPV2 | NPC1 1133/4885RAB9A 3142/4885HTT 3355/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.