Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MTHFD2 | P13995 | 1/20 | 0.36 |
| ▸ | PTGES | O14684 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10004597 | 0.87 | F10 (0.42) | KMT2AALDH1A1TP53TSHRALOX15 | |
| SCHEMBL11990822 | 0.81 | CXCR6 (0.40) | KMT2AMAPTALDH1A1TP53TSHR | |
| SCHEMBL10004586 | 0.80 | KMT2A (0.48) | KMT2AMAPTALDH1A1TP53TSHR | |
| SCHEMBL11990855 | 0.79 | KMT2A (0.47) | KMT2AMAPTALDH1A1TP53TSHR | |
| SCHEMBL10293228 | 0.79 | KMT2A (0.40) | KMT2AALDH1A1TP53TSHRALOX15 | |
| SCHEMBL10004944 | 0.78 | KMT2A (0.50) | KMT2AMAPTALDH1A1TP53TSHR | |
| SCHEMBL10003686 | 0.78 | PTGES (0.48) | KMT2AMAPTALDH1A1TP53TSHR | |
| SCHEMBL10292547 | 0.77 | POLB (0.44) | KMT2AMAPTALDH1A1TP53TSHR | |
| SCHEMBL10003864 | 0.77 | SMO (0.44) | KMT2AALDH1A1TP53TSHRALOX15 | |
| SCHEMBL10292542 | 0.77 | KMT2A (0.44) | KMT2AMAPTALDH1A1TP53TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2471793-B1 | FUSED HETEROCYCLIC RING DERIVATIVE AND USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2016-10-05 | — | — | EP | disclosed |