Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.31 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5562115 | 0.75 | HRH4 (0.34) | — | |
| SCHEMBL1812014 | 0.75 | NR1H3 (0.35) | NR1H2NR1H3 | |
| SCHEMBL1808392 | 0.71 | NR1H3 (0.44) | NR1H2NR1H3 | |
| SCHEMBL1812117 | 0.66 | NR1H3 (0.41) | NR1H2NR1H3 | |
| SCHEMBL1808697 | 0.61 | NR1H3 (0.43) | NR1H2NR1H3 | |
| SCHEMBL1812016 | 0.60 | NR1H2 (0.39) | NR1H2NR1H3 | |
| SCHEMBL1812437 | 0.59 | NR1H3 (0.44) | NR1H2NR1H3 | |
| SCHEMBL4415616 | 0.59 | NR1H2 (0.45) | NR1H2NR1H3 | |
| SCHEMBL1808918 | 0.58 | MAPT (0.42) | NR1H2NR1H3 | |
| SCHEMBL11481517 | 0.58 | RORC (0.44) | NR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4682192-B2 | — | — | 2011-05-11 | — | — | JP | claimed |
| EP-1756096-A1 | INDOLYL DERIVATIVES AS LIVER-X-RECEPTOR MODULATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-02-28 | — | — | EP | claimed |
| WO-2005105791-A1 | INDOLYL DERIVATIVES AS LIVER-X-RECEPTOR MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-11-10 | — | — | WO | claimed |
| EP-1756096-A1 | INDOLYL DERIVATIVES AS LIVER-X-RECEPTOR MODULATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005105791-A1 | INDOLYL DERIVATIVES AS LIVER-X-RECEPTOR MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-11-10 | — | — | WO | disclosed |