Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
| ▸ | RORA | P35398 | 2/20 | 0.33 |
| ▸ | RORC | P51449 | 2/20 | 0.33 |
| ▸ | RORB | Q92753 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1812012 | 0.75 | NR1H2 (0.31) | — | |
| SCHEMBL5562118 | 0.73 | RORA (0.35) | RORARORCRORB | |
| SCHEMBL1811830 | 0.64 | BRD4 (0.47) | RORARORCRORB | |
| SCHEMBL19606080 | 0.59 | MEN1 (0.44) | RORARORC | |
| SCHEMBL309960 | 0.58 | NR1H2 (0.52) | RORARORC | |
| SCHEMBL5562121 | 0.58 | PPARG (0.55) | — | |
| SCHEMBL1811056 | 0.57 | PGR (0.47) | RORARORCRORB | |
| SCHEMBL5067200 | 0.56 | SMN1; SMN2 (0.49) | RORARORC | |
| SCHEMBL1808753 | 0.55 | PGR (0.46) | RORARORCRORB | |
| SCHEMBL6816283 | 0.55 | NR1H2 (0.50) | RORARORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1756096-A1 | INDOLYL DERIVATIVES AS LIVER-X-RECEPTOR MODULATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005105791-A1 | INDOLYL DERIVATIVES AS LIVER-X-RECEPTOR MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-11-10 | — | — | WO | disclosed |