SCHEMBL18121305

SCHEMBL18121305

Cc1ccc(C(F)(F)F)c(NC(=O)[C@H]2CC[C@H]3[C@@H]4CC[C@H]5NC(=O)C=C[C@]5(C)[C@H]4CC[C@]23C)c1

nearest known ligand 0.85

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ SRD5A1 P18405 19/20 0.85
▸ SRD5A2 P31213 8/20 0.85
▸ LMNA P02545 1/20 0.85
▸ ABCB11 O95342 1/20 0.85
▸ GLRA1 P23415 1/20 0.85
▸ KEAP1 Q14145 1/20 0.85
▸ NFE2L2 Q16236 1/20 0.85

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10000656 1.00 SRD5A1 (0.85) SRD5A1SRD5A2LMNAABCB11GLRA1
Dutasteride SCHEMBL1559596 0.92 SRD5A1 (1.00) SRD5A1SRD5A2LMNAABCB11GLRA1
Dutasteride SCHEMBL20776136 0.92 SRD5A1 (1.00) SRD5A1SRD5A2LMNAABCB11GLRA1
Dutasteride SCHEMBL1108295 0.92 SRD5A1 (1.00) SRD5A1SRD5A2LMNAABCB11GLRA1
Dutasteride SCHEMBL5903 0.92 SRD5A1 (1.00) SRD5A1SRD5A2LMNAABCB11GLRA1
Dutasteride SCHEMBL10028296 0.92 SRD5A1 (1.00) SRD5A1SRD5A2LMNAABCB11GLRA1
Dutasteride SCHEMBL4775587 0.92 SRD5A1 (1.00) SRD5A1SRD5A2LMNAABCB11GLRA1
Dutasteride SCHEMBL1832772 0.92 SRD5A1 (1.00) SRD5A1SRD5A2LMNAABCB11GLRA1
Dutasteride SCHEMBL9975973 0.92 SRD5A1 (1.00) SRD5A1SRD5A2LMNAABCB11GLRA1
Dutasteride SCHEMBL12194984 0.92 SRD5A1 (1.00) SRD5A1SRD5A2LMNAABCB11GLRA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11911508-B2 Microparticles containing dutasteride, and preparation method therefor INVENTAGE LAB INC. (KR) 2024-02-27 — — US disclosed
US-20160287524-A1 PHARMACEUTICAL COMPOSITIONS COMPRISING AN ACTIVE AGENT GALENICUM HEALTH S.L. (ES) 2016-10-06 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160287524-A1 PHARMACEUTICAL COMPOSITIONS COMPRISING AN ACTIVE AGENT NR5A1, HSD17B11, UGT2B17 SRD5A1 20/4885SRD5A2 21/4885LMNA 1114/4885
US-11911508-B2 Microparticles containing dutasteride, and preparation method therefor AR, BPHL, SHBG SRD5A1 14/4885SRD5A2 22/4885LMNA 2965/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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