Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMAD3 | P84022 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.57 |
| ▸ | HPGD | P15428 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | F7 | P08709 | 1/20 | 0.57 |
| ▸ | F3 | P13726 | 1/20 | 0.57 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.57 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
| ▸ | APEX1 | P27695 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | DAO | P14920 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15642666 | 0.91 | SMAD3 (0.53) | SMAD3KDM4EHSD17B10HPGDALDH1A1 | |
| SCHEMBL25044341 | 0.90 | SMAD3 (0.51) | SMAD3KDM4EHSD17B10HPGDALDH1A1 | |
| SCHEMBL15642554 | 0.87 | HRH4 (0.54) | SMAD3KDM4EHSD17B10HPGDALDH1A1 | |
| SCHEMBL20494813 | 0.87 | HSD17B10 (0.53) | SMAD3KDM4EHSD17B10HPGDALDH1A1 | |
| SCHEMBL15642795 | 0.86 | SMAD3 (0.50) | SMAD3KDM4EHSD17B10HPGDALDH1A1 | |
| SCHEMBL15642556 | 0.84 | SMAD3 (0.49) | SMAD3KDM4EHSD17B10HPGDALDH1A1 | |
| SCHEMBL15642749 | 0.84 | FGFR1 (0.53) | SMAD3KDM4EHSD17B10HPGDALDH1A1 | |
| SCHEMBL15642686 | 0.84 | PIN1 (0.48) | SMAD3KDM4EHSD17B10HPGDALDH1A1 | |
| Hydrochloric Acid SCHEMBL15642843 | 0.83 | FGFR1 (0.52) | SMAD3KDM4EHSD17B10HPGDALDH1A1 | |
| SCHEMBL15642810 | 0.82 | HRH4 (0.49) | SMAD3KDM4EHSD17B10HPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016160677-A1 | COMPOUNDS FOR THE TREATMENT OF ARENAVIRUS INFECTION | ARISAN THERAPEUTICS INC. (US) | 2016-10-06 | — | — | WO | disclosed |