Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | DAO | P14920 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.53 |
| ▸ | EIF4A3 | P38919 | 2/20 | 0.53 |
| ▸ | MMP9 | P14780 | 3/20 | 0.50 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.49 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.46 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | F7 | P08709 | 1/20 | 0.45 |
| ▸ | F3 | P13726 | 1/20 | 0.45 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.45 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | APEX1 | P27695 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18127380 | 0.87 | SMAD3 (0.58) | HSD17B10KDM4EHPGDDAOMAPT | |
| SCHEMBL17226839 | 0.82 | MMP9 (0.47) | KDM4EMMP9DGAT1LMNAFGFR1 | |
| SCHEMBL31273139 | 0.80 | KDM4E (0.46) | HSD17B10KDM4EHPGDMMP9DGAT1 | |
| SCHEMBL28011584 | 0.80 | MMP9 (0.45) | EIF4A3MMP9DGAT1FGFR1FGFR2 | |
| SCHEMBL15642666 | 0.79 | SMAD3 (0.53) | HSD17B10KDM4EHPGDDAOMAPT | |
| SCHEMBL21354823 | 0.79 | ALOX15 (0.64) | HSD17B10KDM4EHPGDMAPTMMP9 | |
| SCHEMBL25044341 | 0.78 | SMAD3 (0.51) | HSD17B10KDM4EHPGDDAOMAPT | |
| SCHEMBL15642554 | 0.76 | HRH4 (0.54) | HSD17B10KDM4EHPGDSMAD3ALDH1A1 | |
| SCHEMBL31423285 | 0.75 | ACMSD (0.52) | HSD17B10KDM4EHPGDMMP9ALDH1A1 | |
| SCHEMBL31273616 | 0.75 | ACMSD (0.49) | HSD17B10KDM4EHPGDMMP9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110770224-B | Indole derivatives as efflux pump inhibitors | 罗格斯新泽西州立大学 | 2022-11-18 | — | — | CN | disclosed |
| US-20210094912-A1 | INDOLE DERIVATIVES AS EFFLUX PUMP INHIBITORS | RUTGERS, THE STATE UNIVERISTY OF NEW JERSEY (US) | 2021-04-01 | — | — | US | disclosed |
| CN-110770224-A | Indole derivatives as efflux pump inhibitors | 罗格斯新泽西州立大学 | 2020-02-07 | — | — | CN | disclosed |
| WO-2018165611-A1 | INDOLE DERIVATIVES AS EFFLUX PUMP INHIBITORS | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2018-09-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210094912-A1 | INDOLE DERIVATIVES AS EFFLUX PUMP INHIBITORS | ABCB11, ABCB1, ABCG2 | HSD17B10 709/4885KDM4E 4186/4885HPGD 120/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.