Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.40 |
| ▸ | ABL1 | P00519 | 2/20 | 0.40 |
| ▸ | RET | P07949 | 2/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | CDK7 | P50613 | 2/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.40 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | PAK4 | O96013 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL621588 | 0.80 | KDM4E (0.55) | KDM4EKMT2APDGFRBMAPK1PDGFRA | |
| SCHEMBL26919701 | 0.79 | HTT (0.44) | MAPK1ABL1RETKDRCDK7 | |
| SCHEMBL28258845 | 0.79 | KDM4E (0.48) | KDM4EKMT2APDGFRBMAPK1PDGFRA | |
| SCHEMBL621353 | 0.76 | ALDH1A1 (0.52) | KDM4EKMT2APDGFRBMAPK1PDGFRA | |
| SCHEMBL1809475 | 0.76 | NQO2 (0.50) | KDM4EMAPK1ABL1RETKDR | |
| SCHEMBL19674039 | 0.76 | KMT2A (0.48) | KDM4EKMT2APDGFRBPDGFRAABL1 | |
| SCHEMBL1256925 | 0.76 | FGFR3 (0.46) | KDM4EKMT2APDGFRBMAPK1PDGFRA | |
| SCHEMBL13728317 | 0.76 | PDGFRB (0.46) | KDM4EKMT2APDGFRBPDGFRACSF1R | |
| SCHEMBL31500116 | 0.72 | CYP1A2 (0.44) | KDM4EKMT2APDGFRBPDGFRABACE1 | |
| SCHEMBL14352496 | 0.72 | CYP1A2 (0.44) | KDM4EKMT2APDGFRBPDGFRABACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2321296-A1 | SUBSTITUTED 5-AMINOPYRAZOLES AND USE THEREOF | Bayer Schering Pharma Aktiengesellschaft (DE) | 2011-05-18 | — | — | EP | disclosed |
| WO-2010020363-A1 | SUBSTITUTED 5-AMINOPYRAZOLES AND USE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-02-25 | — | — | WO | disclosed |