Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 3/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18130729 | 0.84 | GLRA3 (0.39) | HIF1ACYP2C9CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL18130724 | 0.83 | DGAT1 (0.36) | HIF1ACYP2C9CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL18130728 | 0.80 | NOTUM (0.40) | HIF1ACYP2C9CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL13763260 | 0.74 | GLRA3 (0.45) | HSD17B10CYP3A4ALOX15TDP1RAB9A | |
| SCHEMBL16408244 | 0.70 | CES2 (0.45) | ALDH1A1ALOX15GAAMAPTRXRA | |
| SCHEMBL17781486 | 0.69 | RXRB (0.44) | ALDH1A1CYP3A4MAPTRXRARXRB | |
| SCHEMBL21695140 | 0.69 | NOTUM (0.41) | HIF1ACYP2C9CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL13763261 | 0.69 | CA1 (0.39) | ALDH1A1CYP3A4HPGDTDP1RAB9A | |
| SCHEMBL1085223 | 0.69 | DGAT1 (0.41) | ALDH1A1ALOX15RAB9AGAAMAPT | |
| SCHEMBL3652875 | 0.68 | CA1 (0.46) | HIF1ACYP2C9CYP1A2CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3280419-B1 | INDAZOLE AND AZAINDAZOLE BTK INHIBITORS | MERCK SHARP & DOHME (US) | 2019-10-30 | — | — | EP | disclosed |
| US-10246457-B2 | Indazole and azaindazole Btk inhibitors | MERCK SHARP & DOHME CORP. (US) | 2019-04-02 | — | — | US | disclosed |
| US-20180127411-A1 | INDAZOLE AND AZAINDAZOLE BTK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2018-05-10 | — | — | US | disclosed |
| EP-3280419-A1 | INDAZOLE AND AZAINDAZOLE BTK INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2018-02-14 | — | — | EP | disclosed |
| WO-2016164285-A1 | INDAZOLE AND AZAINDAZOLE BTK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2016-10-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180127411-A1 | INDAZOLE AND AZAINDAZOLE BTK INHIBITORS | BTK, SYK, ABL1 | HIF1A 4549/4885CYP2C9 561/4885CYP1A2 1474/4885 |
| US-10246457-B2 | Indazole and azaindazole Btk inhibitors | BTK, SYK, ABL1 | HIF1A 4549/4885CYP2C9 561/4885CYP1A2 1474/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.