Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.37 |
| ▸ | MEN1 | O00255 | 6/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18131712 | 0.78 | TSHR (0.45) | MAPTMEN1KMT2AALDH1A1CRHBP | |
| SCHEMBL30466489 | 0.78 | TSHR (0.45) | MAPTMEN1KMT2AALDH1A1CRHBP | |
| SCHEMBL18131697 | 0.74 | FGFR4 (0.40) | MAPTMEN1KMT2AALDH1A1MAPK1 | |
| SCHEMBL1285214 | 0.74 | CYP1A2 (0.44) | MAPTMEN1KMT2AALDH1A1CRHBP | |
| SCHEMBL15412383 | 0.73 | TSHR (0.45) | MAPTMEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL14858457 | 0.71 | ERN1 (0.45) | MAPTMEN1KMT2AALDH1A1CRHBP | |
| SCHEMBL21386604 | 0.71 | FGFR4 (0.37) | — | |
| SCHEMBL18299606 | 0.70 | CYP1A2 (0.47) | MAPTALDH1A1CYP1A2TDP1CYP3A4 | |
| SCHEMBL1632654 | 0.69 | ALDH1A1 (0.48) | MAPTMEN1KMT2AALDH1A1NPSR1 | |
| SCHEMBL3645259 | 0.68 | ALDH1A1 (0.64) | MAPTMEN1KMT2AALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016164703-A1 | FGFR4 INHIBITORS | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2016-10-13 | — | — | WO | disclosed |
| WO-2016164703-A1 | FGFR4 INHIBITORS | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2016-10-13 | — | — | WO | disclosed |