Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 8/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.34 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | TDO2 | P48775 | 1/20 | 0.31 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.31 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.31 |
| ▸ | RPS6KB2 | Q9UBS0 | 1/20 | 0.31 |
| ▸ | PLK1 | P53350 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18131690 | 0.85 | FGFR4 (0.50) | FGFR4MAPK1FGFR1CYP3A4CYP2D6 | |
| SCHEMBL18131708 | 0.82 | MAPT (0.39) | FGFR4MAPK1FGFR1CYP2C9CYP2C19 | |
| SCHEMBL18131808 | 0.80 | FGFR4 (0.51) | FGFR4EGFRFGFR1CYP2D6ALDH1A1 | |
| SCHEMBL23314963 | 0.80 | FGFR4 (0.52) | FGFR4MAPK1FGFR1ALDH1A1MAPT | |
| SCHEMBL15413220 | 0.75 | FGFR4 (0.63) | FGFR4FGFR1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL18131745 | 0.74 | MAPT (0.37) | MAPK1CYP3A4CYP2C19ALDH1A1MAPT | |
| SCHEMBL21386604 | 0.73 | FGFR4 (0.37) | FGFR4FGFR1FGFR2FGFR3RPS6KB2 | |
| SCHEMBL18134023 | 0.73 | FGFR4 (0.51) | FGFR4FGFR1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL15413168 | 0.69 | FGFR4 (0.60) | FGFR4MAPK1FGFR1CYP3A4CYP2D6 | |
| SCHEMBL18134024 | 0.68 | FGFR1 (0.39) | FGFR4FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016164703-A1 | FGFR4 INHIBITORS | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2016-10-13 | — | — | WO | disclosed |
| WO-2016164703-A1 | FGFR4 INHIBITORS | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2016-10-13 | — | — | WO | disclosed |