Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | BLM | P54132 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | THPO | P40225 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.40 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | BMP1 | P13497 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12661034 | 1.00 | CHRM2 (0.42) | CHRM2CHRM4CHRM1ALOX15BLM | |
| SCHEMBL24158322 | 0.92 | SIRT5 (0.43) | CHRM2CHRM4CHRM1ALOX15BLM | |
| SCHEMBL17192782 | 0.87 | SIRT5 (0.50) | ALOX15BLMKDM4EMAPTTHRB | |
| SCHEMBL5707637 | 0.86 | ALOX15 (0.44) | CHRM2CHRM4CHRM1ALOX15BLM | |
| SCHEMBL287578 | 0.86 | ALOX15 (0.53) | ALOX15BLMKDM4EMAPTTHRB | |
| SCHEMBL287577 | 0.86 | ALOX15 (0.53) | ALOX15BLMKDM4EMAPTTHRB | |
| SCHEMBL6026388 | 0.86 | ALOX15 (0.53) | ALOX15BLMKDM4EMAPTTHRB | |
| SCHEMBL6445997 | 0.86 | ALOX15 (0.53) | ALOX15BLMKDM4EMAPTTHRB | |
| SCHEMBL1764311 | 0.85 | SIRT5 (0.51) | CHRM2CHRM4CHRM1ALOX15BLM | |
| SCHEMBL1764312 | 0.85 | SIRT5 (0.51) | CHRM2CHRM4CHRM1ALOX15BLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210395244-A1 | MITOGEN-ACTIVATED PROTEIN KINASE KINASE (MEK) DEGRADATION COMPOUNDS AND METHODS OF USE | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI | 2021-12-23 | — | — | US | disclosed |
| US-20160298105-A1 | CELL SEPARATION METHOD USING A RELEASE SYSTEM FOR CELL-ANTIBODY-SUBSTRATE CONJUGATES CONTAINING A POLYETHYLENE GLYCOL SPACER UNIT | MILTENYI BIOTEC GMBH (DE) | 2016-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210395244-A1 | MITOGEN-ACTIVATED PROTEIN KINASE KINASE (MEK) DEGRADATION COMPOUNDS AND METHODS OF USE | MAP2K2, MAP2K1, MAP2K7 | CHRM2 4182/4885CHRM4 4576/4885CHRM1 4450/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.