Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 12/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.35 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15434003 | 0.87 | FGFR4 (0.65) | FGFR4FGFR1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL18131690 | 0.84 | FGFR4 (0.50) | FGFR4FGFR1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL15434004 | 0.81 | FGFR4 (0.62) | FGFR4 | |
| SCHEMBL18131836 | 0.79 | FGFR4 (0.81) | FGFR4FGFR1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL18133990 | 0.79 | FGFR3 (0.50) | FGFR4FGFR1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL21386622 | 0.79 | FGFR4 (0.65) | FGFR4FGFR1CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL18134024 | 0.77 | FGFR1 (0.39) | FGFR4FGFR1 | |
| SCHEMBL18134032 | 0.76 | FGFR1 (0.52) | FGFR4FGFR1FGFR2FGFR3 | |
| SCHEMBL15244317 | 0.75 | PDGFRB (0.35) | — | |
| SCHEMBL15725730 | 0.73 | KDR (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016164703-A1 | FGFR4 INHIBITORS | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2016-10-13 | — | — | WO | disclosed |