Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 9/20 | 0.52 |
| ▸ | FGFR4 | P22455 | 8/20 | 0.52 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | RAD52 | P43351 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 5/20 | 0.35 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 2/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18134024 | 0.88 | FGFR1 (0.39) | FGFR1FGFR4MTORPIK3CA | |
| SCHEMBL18131808 | 0.87 | FGFR4 (0.51) | FGFR1FGFR4CHEK1GAAPDGFRB | |
| SCHEMBL18134162 | 0.84 | FGFR4 (0.71) | FGFR1FGFR4FGFR3FGFR2 | |
| SCHEMBL18131815 | 0.84 | FGFR4 (0.75) | FGFR1FGFR4FGFR3FGFR2 | |
| SCHEMBL18134167 | 0.81 | FGFR4 (0.67) | FGFR1FGFR4FGFR3FGFR2 | |
| SCHEMBL21386624 | 0.78 | FGFR1 (0.48) | FGFR1FGFR4GAARAD52PDGFRB | |
| SCHEMBL21756489 | 0.77 | FGFR4 (0.47) | FGFR1FGFR4GAARAD52PDGFRB | |
| SCHEMBL18134023 | 0.76 | FGFR4 (0.51) | FGFR1FGFR4FGFR3FGFR2 | |
| SCHEMBL30262070 | 0.75 | FGFR4 (0.46) | FGFR1FGFR4PDGFRBPDGFRAFGFR3 | |
| SCHEMBL18131708 | 0.75 | MAPT (0.39) | FGFR1FGFR4MAPTMAPK1PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016164703-A1 | FGFR4 INHIBITORS | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2016-10-13 | — | — | WO | disclosed |