Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 4/20 | 0.39 |
| ▸ | FGFR4 | P22455 | 4/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 10/20 | 0.39 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
| ▸ | INSR | P06213 | 1/20 | 0.37 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18134032 | 0.88 | FGFR1 (0.52) | FGFR1FGFR4PIK3CAMTOR | |
| SCHEMBL18131708 | 0.86 | MAPT (0.39) | FGFR1FGFR4PIK3CAPKMYT1 | |
| SCHEMBL18131695 | 0.83 | FGFR4 (0.60) | FGFR1FGFR4 | |
| SCHEMBL18134043 | 0.82 | FGFR4 (0.57) | FGFR1FGFR4 | |
| SCHEMBL18134023 | 0.77 | FGFR4 (0.51) | FGFR1FGFR4 | |
| SCHEMBL18131808 | 0.75 | FGFR4 (0.51) | FGFR1FGFR4KITFLT3INSR | |
| SCHEMBL18131815 | 0.72 | FGFR4 (0.75) | FGFR1FGFR4 | |
| SCHEMBL18134162 | 0.71 | FGFR4 (0.71) | FGFR1FGFR4 | |
| SCHEMBL18131707 | 0.69 | FGFR4 (0.56) | FGFR1FGFR4 | |
| SCHEMBL18134167 | 0.68 | FGFR4 (0.67) | FGFR1FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016164703-A1 | FGFR4 INHIBITORS | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2016-10-13 | — | — | WO | disclosed |