Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 9/20 | 0.71 |
| ▸ | FGFR1 | P11362 | 8/20 | 0.71 |
| ▸ | FGFR3 | P22607 | 11/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.46 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18134167 | 0.97 | FGFR4 (0.67) | FGFR4FGFR1FGFR3CYP3A4CYP2D6 | |
| SCHEMBL18134043 | 0.89 | FGFR4 (0.57) | FGFR4FGFR1FGFR3CYP3A4CYP2D6 | |
| SCHEMBL18131810 | 0.87 | FGFR1 (0.70) | FGFR4FGFR1FGFR3CYP3A4CYP2D6 | |
| SCHEMBL18134022 | 0.85 | FGFR1 (0.59) | FGFR4FGFR1FGFR3CYP3A4CYP2D6 | |
| SCHEMBL18134032 | 0.84 | FGFR1 (0.52) | FGFR4FGFR1FGFR3FGFR2 | |
| SCHEMBL18134166 | 0.84 | FGFR4 (0.66) | FGFR4FGFR1FGFR3CYP3A4CYP2D6 | |
| SCHEMBL18131804 | 0.83 | FGFR4 (1.00) | FGFR4FGFR1FGFR3CYP3A4CYP2D6 | |
| SCHEMBL21756489 | 0.79 | FGFR4 (0.47) | FGFR4FGFR1FGFR3FGFR2 | |
| SCHEMBL21386624 | 0.78 | FGFR1 (0.48) | FGFR4FGFR1FGFR3FGFR2 | |
| SCHEMBL21386622 | 0.77 | FGFR4 (0.65) | FGFR4FGFR1FGFR3CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016164703-A1 | FGFR4 INHIBITORS | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2016-10-13 | — | — | WO | disclosed |