Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 8/20 | 0.66 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.66 |
| ▸ | FGFR3 | P22607 | 11/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.43 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18131810 | 0.97 | FGFR1 (0.70) | FGFR4FGFR1FGFR3CYP2D6CYP3A4 | |
| SCHEMBL18134167 | 0.87 | FGFR4 (0.67) | FGFR4FGFR1FGFR3CYP2D6CYP3A4 | |
| SCHEMBL18131707 | 0.86 | FGFR4 (0.56) | FGFR4FGFR1FGFR3CYP2D6CYP3A4 | |
| SCHEMBL18134162 | 0.84 | FGFR4 (0.71) | FGFR4FGFR1FGFR3CYP2D6CYP3A4 | |
| SCHEMBL18131825 | 0.83 | FGFR1 (0.58) | FGFR4FGFR1FGFR3CYP2D6CYP3A4 | |
| SCHEMBL18131808 | 0.82 | FGFR4 (0.51) | FGFR4FGFR1FGFR3CYP2D6FGFR2 | |
| SCHEMBL18131804 | 0.79 | FGFR4 (1.00) | FGFR4FGFR1FGFR3CYP2D6CYP3A4 | |
| SCHEMBL21756598 | 0.77 | FGFR1 (0.48) | FGFR4FGFR1FGFR3CYP2D6FGFR2 | |
| SCHEMBL18134169 | 0.76 | FGFR4 (0.86) | FGFR4FGFR1FGFR3CYP2D6CYP3A4 | |
| SCHEMBL21386671 | 0.75 | FGFR4 (0.64) | FGFR4FGFR1FGFR3CYP2D6CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016164703-A1 | FGFR4 INHIBITORS | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2016-10-13 | — | — | WO | disclosed |