Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 7/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.33 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.33 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | INSR | P06213 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18131708 | 0.89 | MAPT (0.39) | FGFR4FGFR1ALDH1A1L3MBTL1KMT2A | |
| SCHEMBL18134032 | 0.87 | FGFR1 (0.52) | FGFR4FGFR1CHEK1MAPTPDGFRA | |
| SCHEMBL18131810 | 0.85 | FGFR1 (0.70) | FGFR4FGFR1CYP2D6FGFR2FGFR3 | |
| SCHEMBL18131815 | 0.82 | FGFR4 (0.75) | FGFR4FGFR1CYP2D6FGFR2FGFR3 | |
| SCHEMBL18134166 | 0.82 | FGFR4 (0.66) | FGFR4FGFR1ALDH1A1CYP2D6L3MBTL1 | |
| SCHEMBL18131697 | 0.80 | FGFR4 (0.40) | FGFR4FGFR1ALDH1A1CYP2D6KMT2A | |
| SCHEMBL21756598 | 0.79 | FGFR1 (0.48) | FGFR4FGFR1ALDH1A1CYP2D6L3MBTL1 | |
| SCHEMBL18131690 | 0.78 | FGFR4 (0.50) | FGFR4FGFR1ALDH1A1CYP2D6L3MBTL1 | |
| SCHEMBL18134024 | 0.75 | FGFR1 (0.39) | FGFR4FGFR1JAK2INSRKIT | |
| SCHEMBL18131707 | 0.74 | FGFR4 (0.56) | FGFR4FGFR1CYP2D6FGFR2FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016164703-A1 | FGFR4 INHIBITORS | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2016-10-13 | — | — | WO | disclosed |
| WO-2016164703-A1 | FGFR4 INHIBITORS | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2016-10-13 | — | — | WO | disclosed |