Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLP1R | P43220 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | XBP1 | P17861 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.48 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.47 |
| ▸ | GABRA2 | P47869 | 9/20 | 0.46 |
| ▸ | GABRB2 | P47870 | 9/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19951147 | 0.87 | CYP1A2 (0.47) | GLP1RCYP1A2ALDH1A1NPC1MAPT | |
| SCHEMBL10382598 | 0.87 | ALDH1A1 (0.50) | GLP1RCYP1A2ALDH1A1NPC1MAPT | |
| SCHEMBL18132216 | 0.86 | CYP1A2 (0.46) | GLP1RCYP1A2ALDH1A1NPC1MAPT | |
| SCHEMBL18132275 | 0.84 | CYP1A2 (0.45) | GLP1RCYP1A2ALDH1A1NPC1MAPT | |
| SCHEMBL18137436 | 0.83 | GLP1R (0.47) | GLP1RCYP1A2ALDH1A1NPC1MAPT | |
| SCHEMBL18137437 | 0.83 | CYP1A2 (0.46) | GLP1RCYP1A2ALDH1A1NPC1MAPT | |
| SCHEMBL18137428 | 0.83 | CYP1A2 (0.46) | GLP1RCYP1A2ALDH1A1NPC1MAPT | |
| SCHEMBL18137434 | 0.83 | GLP1R (0.47) | GLP1RCYP1A2ALDH1A1NPC1MAPT | |
| SCHEMBL19951135 | 0.81 | CYP1A2 (0.45) | GLP1RCYP1A2ALDH1A1NPC1MAPT | |
| SCHEMBL18137651 | 0.81 | GLP1R (0.46) | GLP1RCYP1A2ALDH1A1NPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107531693-B | 5 or 8-substituted imidazo [1, 5-a ] pyridines as indoleamine, tryptophan dioxygenase inhibitors | 百济神州有限公司 | 2021-07-06 | — | — | CN | disclosed |
| EP-3280715-B1 | NOVEL 5 OR 8-SUBSTITUTED IMIDAZO [1, 5-a]PYRIDINES AS INDOLEAMINE AND/OR TRYPTOPHANE 2, 3-DIOXYGENASES | BEIGENE LTD (KY) | 2020-11-25 | — | — | EP | disclosed |
| EP-3280715-B1 | NOVEL 5 OR 8-SUBSTITUTED IMIDAZO [1, 5-a]PYRIDINES AS INDOLEAMINE AND/OR TRYPTOPHANE 2, 3-DIOXYGENASES | BEIGENE LTD (KY) | 2020-11-25 | — | — | EP | disclosed |
| US-10647714-B2 | 5 or 8-substituted imidazo[1,5-a]pyridines as indoleamine and/or tryptophane 2,3-dioxygenases | BEIGENE, LTD. (KY) | 2020-05-12 | — | — | US | disclosed |
| CN-110872289-A | Novel 8-substituted imidazo [1,5-a ] pyridines as IDO1 and/or TDO inhibitors | 百济神州(北京)生物科技有限公司 | 2020-03-10 | — | — | CN | disclosed |
| US-20190284184-A1 | NOVEL 5 OR 8-SUBSTITUTED IMIDAZO[1,5-a]PYRIDINES AS INDOLEAMINE AND/OR TRYPTOPHANE 2,3-DIOXYGENASES | BEONE MEDICINES I GMBH (CH) | 2019-09-19 | — | — | US | disclosed |
| US-10280163-B2 | 5 or 8-substituted imidazo[1, 5-a] pyridines as indoleamine and/or tryptophane 2, 3-dioxygenases | BEIGENE, LTD. (KY) | 2019-05-07 | — | — | US | disclosed |
| US-10280163-B2 | 5 or 8-substituted imidazo[1, 5-a] pyridines as indoleamine and/or tryptophane 2, 3-dioxygenases | BEIGENE, LTD. (KY) | 2019-05-07 | — | — | US | disclosed |
| US-20180072716-A1 | NOVEL 5 OR 8-SUBSTITUTED IMIDAZO[1, 5-a] PYRIDINES AS INDOLEAMINE AND/OR TRYPTOPHANE 2, 3-DIOXYGENASES | BEONE MEDICINES I GMBH (CH) | 2018-03-15 | — | — | US | disclosed |
| US-20180072716-A1 | NOVEL 5 OR 8-SUBSTITUTED IMIDAZO[1, 5-a] PYRIDINES AS INDOLEAMINE AND/OR TRYPTOPHANE 2, 3-DIOXYGENASES | BEONE MEDICINES I GMBH (CH) | 2018-03-15 | — | — | US | disclosed |
| US-20180072716-A1 | NOVEL 5 OR 8-SUBSTITUTED IMIDAZO[1, 5-a] PYRIDINES AS INDOLEAMINE AND/OR TRYPTOPHANE 2, 3-DIOXYGENASES | BEONE MEDICINES I GMBH (CH) | 2018-03-15 | — | — | US | disclosed |
| WO-2016161960-A1 | NOVEL 5 OR 8-SUBSTITUTED IMIDAZO [1, 5-a] PYRIDINES AS INDOLEAMINE AND/OR TRYPTOPHANE 2, 3-DIOXYGENASES | BEIGENE, LTD. (KY) | 2016-10-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10280163-B2 | 5 or 8-substituted imidazo[1, 5-a] pyridines as indoleamine and/or tryptophane 2, 3-dioxygenases | IDO1, TPH1, IDO2 | GLP1R 1020/4885CYP1A2 66/4885ALDH1A1 466/4885 |
| US-10647714-B2 | 5 or 8-substituted imidazo[1,5-a]pyridines as indoleamine and/or tryptophane 2,3-dioxygenases | IDO1, TPH1, IDO2 | GLP1R 1020/4885CYP1A2 66/4885ALDH1A1 466/4885 |
| US-20190284184-A1 | NOVEL 5 OR 8-SUBSTITUTED IMIDAZO[1,5-a]PYRIDINES AS INDOLEAMINE AND/OR TRYPTOPHANE 2,3-DIOXYGENASES | IDO1, TPH1, IDO2 | GLP1R 976/4885CYP1A2 72/4885ALDH1A1 434/4885 |
| US-20180072716-A1 | NOVEL 5 OR 8-SUBSTITUTED IMIDAZO[1, 5-a] PYRIDINES AS INDOLEAMINE AND/OR TRYPTOPHANE 2, 3-DIOXYGENASES | IDO1, TPH1, IDO2 | GLP1R 968/4885CYP1A2 72/4885ALDH1A1 440/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.